Liver

Question 1

KGR?

Answer 1

> 2 % per week assoc with less liver failure (2.66 in msk series)

Question 2

Fong criteria?

Answer 2

• CEA >200
• <12 months from primary
• > 1 tumor
• > 5cm
• > Node positive primary

Question 3

EORTC 40983 trial CRLM?

Answer 3

Surgery alone vs periop FOLFOX (6 + 6) + surgery for < 5 CRLM
** No OS benefit to periop chemo in CRLM
* Improved PFS

Question 4

JCOG adjuvant CRLM trial?

Answer 4

• Surgery alone vs surgery + adjuvant FOLFOX for CRS with unlimited CRLM
• No OS benefit to adjuvant chemo in CRLM
• Improved PFS with chemo

Question 5

Chemo hepatotoxicity?

Answer 5

Oxaliplatin- venous congestion, blue liver
Irinotecan- Stetohepatitis
5-FU- steatosis

Question 6

HCC imaging features?

Answer 6

• Arterial enhancement with delayed washout
• Pseudocapsule

Question 7

Milan criteria?

Answer 7

Single tumor <5cm
Up to 3 tumors < 3 cm

Question 8

Extended or UCSF criteria?

Answer 8

• Single lesion < 6.5 cm
• Multiple lesions largest < 4.5cm and total tumor dimension < 8 cm

Question 9

HCC worst prognostic factors?

Answer 9

Fibrosis/cirrhosis
Vascular invasion
Lack of capsule
High grade

Question 10

HCC recommended margins?

Answer 10

Negative margins (no difference wide or narrow)
Poor prognostic factors (satellite nodules and positive margin)