Lymphoma - Hodgkin Lymphoma Flashcards
Hodgkin lymphoma (HL) is essentially a tumour derived from lymphocytes, specifically B and T cells. What is the incidence of NHL?
1 - 2.7 / 100,000
2 - 2.7 / 10,000
3 - 2.7 / 1000
4 - 2.7 / 100
1 - 2.7 / 100,000
- males at increased risk
- accounts for 30% of all lymphomas
Hodgkin lymphoma (HL) is essentially a tumour derived from lymphocytes, specifically B and T cells. What ages is most at risk of developing HL?
1 - 2-10 and >30
2 - 10-15 and >40
3 - 15-30 and >50
4 - 40-60 and >85
3 - 15-30 and >50
Although the exact cause of Hodgkin Lymphoma (HL) is unknown, which 2 viruses have been associated with HL?
1 - HIV
2 - EBV
3 - HPV
4 - CMV
1 - HIV
2 - EBV
When comparing leukaemia and lymphoma, which is a solid and which is a liquid tumour?
- leukaemia = liquid (blood)
- lymphoma = solid (lymph nodes)
To distinguish between Non-hodgkin lymphoma (NHL) or Hodgkin lymphoma we use a specific cell, what is this cell?
1 - reed sternberg cells
2 - cytomegalovirus
3 - aeur rods on blood smears
4 - raised basophils
1 - reed sternberg cells
Reed sternberg cells are what we can use to distinguish between Non-hodgkin lymphoma (NHL) or Hodgkin lymphoma. Which of the following is a characteristic of Reed sternberg cells?
1 - large multinucleated cells
2 - don’t produce antibodies
3 - surrounded by inflammatory cells (T cells that secrete cytokines)
4 - fibroblasts surround and become activated
5 - eosinophils are activated
6 - all of the above
6 - all of the above
There are 2 subcategories of Hodgkin lymphoma:
- Nodular lymphocyte predominant Hodgkin Lymphoma (NLPHL)
- Classical Hodgkin Lymphoma (cHL)
In cHL do the the B cells have CD45 and CD20 as normal B cells do?
- no
- instead they have CD15 and CD30
There are 4 subtypes of Classical Hodgkin Lymphoma (cHL) based on histology and the reactive background inflammatory cells and whether fibrosis is present:
- nodular sclerosis cHL
- mixed cellularity cHL
- lymphocyte rich cHL
- lymphocyte depleted cHL
Which of these is the most common form of cHL?
- nodular sclerosis cHL
There are 4 subtypes of Classical Hodgkin Lymphoma (cHL) based on histology and the reactive background inflammatory cells and whether fibrosis is present:
- nodular sclerosis cHL
- mixed cellularity cHL
- lymphocyte rich cHL
- lymphocyte depleted cHL
Which of the subtypes is described below:
1 - tumour contains neoplastic lymphocyte Reed sternberg cells and immune cells
2 - neoplastic cells are surrounded by collagen and fibroblasts
3 - nodules are formed
4 - lacunar cells are present on histology
- nodular sclerosis cHL
There are 4 subtypes of Classical Hodgkin Lymphoma (cHL) based on histology and the reactive background inflammatory cells and whether fibrosis is present:
- nodular sclerosis cHL
- lymphocyte rich cHL
- lymphocyte depleted cHL
- mixed cellularity cHL
Which of the subtypes is described below:
1 - Reed sternberg cells and immune cells are present
2 - eosinophils, plasma cells, lymphocytes, neutrophils and histiocytes surround the Reed sternberg cell
- mixed cellularity cHL
There are 4 subtypes of Classical Hodgkin Lymphoma (cHL) based on histology and the reactive background inflammatory cells and whether fibrosis is present:
- nodular sclerosis cHL
- lymphocyte rich cHL
- lymphocyte depleted cHL
- mixed cellularity cHL
Which of the subtypes is described below:
1 - Reed sternberg cells and immune cells are present
2 - Reed sternberg cell is surrounded by mostly lymphocytes
3 - best prognosis of hodgkin lymphoma subtypes
- lymphocyte rich cHL
There are 4 subtypes of Classical Hodgkin Lymphoma (cHL) based on histology and the reactive background inflammatory cells and whether fibrosis is present:
- nodular sclerosis cHL
- lymphocyte rich cHL
- lymphocyte depleted cHL
- mixed cellularity cHL
Which of the subtypes is described below:
1 - Reed sternberg cells and immune cells are present
2 - no or very few lymphocytes
3 - lots of hodgin and Reed sternberg cells
4 - least common subtype of hodgkin lymphoma
- lymphocyte depleted cHL
There are 2 subcategories of Hodgkin lymphoma:
- Nodular lymphocyte predominant Hodgkin Lymphoma (NLPHL)
- Classical Hodgkin Lymphoma (cHL)
In NLPHL do the the B cells have CD45 and CD20 as normal B cells do?
- yes
- they do not have CD15 or CD30
There are 2 subcategories of Hodgkin lymphoma:
- Nodular lymphocyte predominant Hodgkin Lymphoma (NLPHL)
- Classical Hodgkin Lymphoma (cHL)
In NLPHL, what is present on histology?
1 - just Reed sternberg cells
2 - just lymhocytes
3 - lymphocyte predominant cells
4 - granulocytes only
3 - lymphocyte predominant cells
- contain a lobulated nucleus that looks like popcorn
- surrounded by nodules made from lymphocytes
All of the following are common in patient with Classical Hodgkin Lymphoma (cHL), what is the most commonly presenting symptom?
1 - enlarged, non-tender, rubbery lymph nodes
2 - night sweats, drenching
3 - fever, >38C
4 - weight loss and lethargy
5 - pruritus (itchy skin)
6 - alcohol induced Hodgkins
1 - enlarged, non-tender, rubbery lymph nodes
- 70% of patients have cervical
- axillary and groin are also common