M&R Flashcards
When do you use the concentration response curve?
When looking at a response in tissues or cells
What is a logarhythm?
Exponent by which a value (fixed) has to be raised to give a particular number
When do you use a dose response curve?
When looking at a response in a whole animal
What is the EC50?
The effective concentration that gives 50% of the maximum response
What is the EC50 a measure of?
Potency
What is the IC50?
The inhibitor concentration giving 50% maximum inhibition
What are carbohydrates important for in terms of the cell an membranes?
Cellular and immune recognition
How do carrier molecules move?
Ping pong
When is the NCX used?
Action potential in heart
Reverses in ischaemia so leads to toxicity
How do you work out unmyelinated axons velocity?
It’s proportional to square root of diameter
How do you work out myelinated axons velocity?
It’s proportional to diameter
What are dihydropyramidines used for?
Block L type calcium channels
What G protein does perrsutis toxin work on?
Gi
It stops GDP -> GTP
What G protein does cholera toxin work on?
Gs
Stops GTP -> GDP
What action so micro opioids do?
Reduce calcium
Interact with Gi
