making CAR T cells a solid option for solid tumours Flashcards
learn academic words and scientific expression
endow
provide with a quality/ability/asset
e.g. be endowed with
sentence example: To do so, CAR T cells are
endowed with specific antigen recognition moieties fused to signaling and costimulatory
domains
costimulatory
adj. form of co-stimulation: a secondary signal which immune cells rely on to activate the immune response
in the presence of an antigen-presenting cell
sentence example: To do so, CAR T cells are
endowed with specific antigen recognition moieties fused to signaling and costimulatory
domains
malignancy
describing that the state of presence of the malignant tumour cells is detrimental
sentence example: While this approach has shown great success for the treatment of B cell
malignancies, response rates among patients with solid cancers are less favorable
combinatorial
relating to the selection of a given number of elements from a large number without regarding to their arrangment
sentence example: This review focuses on combinatorial antigen targeting,
regional delivery and approaches to improve CAR T cell persistence in the face of a
hostile tumor microenvironment.
hostile
showing the feeling of opposing or dislike or unfriendly
sentence example: This review focuses on combinatorial antigen targeting,
regional delivery and approaches to improve CAR T cell persistence in the face of a
hostile tumor microenvironment.
relapsed/refractory
deteriorate after a period of improvement/resistant to stimuli
sentence example: Chimeric antigen receptor (CAR) T cells targeting CD19 for the treatment of relapsed/refractory
(r/r) B-cell acute lymphoblastic leukemia (ALL) and lymphoma have led to unprecedented
response rates of about 80% in a patient population that up until then had a very poor
prognosis
unprecedented
never done or known before
sentence example: Chimeric antigen receptor (CAR) T cells targeting CD19 for the treatment of relapsed/refractory
(r/r) B-cell acute lymphoblastic leukemia (ALL) and lymphoma have led to unprecedented
response rates of about 80% in a patient population that up until then had a very poor
prognosis
prognosis
the likely course of a medical condition
sentence example: Chimeric antigen receptor (CAR) T cells targeting CD19 for the treatment of relapsed/refractory
(r/r) B-cell acute lymphoblastic leukemia (ALL) and lymphoma have led to unprecedented
response rates of about 80% in a patient population that up until then had a very poor
prognosis
converging
meeting together
sentence example: The FDA approval of CAR T cells for leukemia and then lymphoma in 2017
marked the breakthrough of two converging clinical research fields: CAR T cell immunotherapy
and gene therapy.
conceive
form or devise (a plan or idea) in the mind
sentence example: . CAR T cells were first conceived by Eshhar and colleagues in 1989 as an
enhanced T cell version endowed with an antibody-based recognition domain fused to a CD3zeta
signaling domain
endeavor
(verb)try hard to do or achieve something
(noun)an attempt to achieve a goal
sentence example: Making the impressive potency of CAR T cell therapy available to the more
numerous patients suffering from solid cancers has been an endeavor for about a decade now
hematological
adj. form of hemotology: Hematology is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood
sentence example: So far, CAR T cells for solid tumors have not been able to achieve the impressive responses induced in hematological cancers
hurdle
a problem or difficulty that must be overcome
one of a series of upright frames over which athletes in a race must jump
sentence example: Multiple approaches aiming at overcoming these hurdles are currently
under active investigation
