Flashcards in Malabsorption, Coeliac disease and tropical sprue Deck (19):
Common causes of malabsorption in the UK?
Rarer causes of malabsorption in UK
Small bowel mucosa deficiencies
Infection/ bacterial overgrowth
What are causes of decreased bile secretion?
Surgical removal of ileum (where bile is reabsorbed) , cholestyramine (medication that removes bile)
What are common causes of pancreatic insufficiency?
CF and pancreatic cancer
What are causes of small bowel mucosa deficiencies?
Small bowel resection
Brush border enzyme deficiencies (lactase)
Drugs: metformin, neomycin, alcohol
What infections can cause malabsorption?
Diphyllobothriasis (B12 malabsorption)
Clinical symptoms of malabsorption?
What deficiency may cause anaemia?
Iron, B12 or folate
What deficiency may cause a bleeding disorder?
What deficiency may cause oedema?
Decreased protein (albumin- leading to low oncotic pressure)
What deficiency may cause metabolic bone disease?
What tests should be performed to find the cause of malabsorption?
Breath hydrogen analysis (test for bacteria)
What blood test results are significant in malabsorption?
MCV- low in iron deficiency, high in folate or B12 deficiency
Low calcium, low iron, low B12 and folate
Raised INR and lipid profile
Coeliac test (looking for antibodies to gluten)
What findings may be significant in stool sample?
Sudan's stain for fat globules
Stool microscopy for:
Alpha 1 antitrypsin (high levels suggests protein loss)
Elastase (low levels suggest pancreas insufficiency)
What causes is barium swallow used to test for in malabsorption?
What is tropical sprue?
A progressive small intestinal disorder. Occurs in residents or visitors to areas in the tropics.
Aetiology is unknown but likely to be infective cause
How does Tropical Sprue present?
Why does tropical sprue cause malabsorption?
Malabsorption of B12 and fat especially