Malabsorption, Coeliac disease and tropical sprue Flashcards Preview

GI and liver > Malabsorption, Coeliac disease and tropical sprue > Flashcards

Flashcards in Malabsorption, Coeliac disease and tropical sprue Deck (19):
1

Common causes of malabsorption in the UK?

Coeliac disease
Chronic pancreatitis
Crohns disease

2

Rarer causes of malabsorption in UK

Decreased bile
Pancreatic insufficiency
Small bowel mucosa deficiencies
Infection/ bacterial overgrowth
Intestinal hurry

3

What are causes of decreased bile secretion?

Biliary cirrhosis,
Biliary obstruction,
Surgical removal of ileum (where bile is reabsorbed) , cholestyramine (medication that removes bile)

4

What are common causes of pancreatic insufficiency?

CF and pancreatic cancer

5

What are causes of small bowel mucosa deficiencies?

Whipples disease
Radiation enteritis
Tropical sprue
Small bowel resection
Brush border enzyme deficiencies (lactase)
Drugs: metformin, neomycin, alcohol
Amyloid

6

What infections can cause malabsorption?

Bacterial overgrowth

Giardiasis (parasitic),
Diphyllobothriasis (B12 malabsorption)
Strongyloidiasis (helminth)

7

Clinical symptoms of malabsorption?

Diarrhoea
Weight loss
Steatorrhea
Lethargy
Bloating

8

What deficiency may cause anaemia?

Iron, B12 or folate

9

What deficiency may cause a bleeding disorder?

Vitamin K
(fat soluble)

10

What deficiency may cause oedema?

Decreased protein (albumin- leading to low oncotic pressure)

11

What deficiency may cause metabolic bone disease?

Vitamin D

12

What tests should be performed to find the cause of malabsorption?

Bloods
Stool sample
Barium swallow
Breath hydrogen analysis (test for bacteria)
Endoscopy

13

What blood test results are significant in malabsorption?

MCV- low in iron deficiency, high in folate or B12 deficiency

Low calcium, low iron, low B12 and folate

Raised INR and lipid profile

Coeliac test (looking for antibodies to gluten)

14

What findings may be significant in stool sample?

Sudan's stain for fat globules

Stool microscopy for:
Alpha 1 antitrypsin (high levels suggests protein loss)
Elastase (low levels suggest pancreas insufficiency)

15

What causes is barium swallow used to test for in malabsorption?

Diverticula,
Crohn’s,
Radiation enteritis

16

What is tropical sprue?

A progressive small intestinal disorder. Occurs in residents or visitors to areas in the tropics.

Aetiology is unknown but likely to be infective cause

17

How does Tropical Sprue present?

Diarrhoea
Steatorrhea
Megaloblastic anaemia.

18

Why does tropical sprue cause malabsorption?

Villous atrophy

Malabsorption of B12 and fat especially

19

Treatment for tropical sprue

Folic acid and tetracycline
Correct nutritional deficiencies