Malignant Heme Drugs Flashcards
What is the MOA of Rituximab?
AB binds to B cell receptor CD20 and induces apoptosis of malignant B cells
What is the indication for Rituximab?
B cell malignancy
What is the MOA of Ruxolitinib?
Blocks JAK (protein that mediates growth factors responsible for hematopoiesis)
What are the indications for Ruxolitinib?
Myleoproliferative neoplasms (MPN): myelofibrosis, PV
What is the MOA of hydroxyurea?
Inhibits DNA synthesis in rapidly dividing cells
What is the indication for hydroxyurea?
Leukemias (quickly dec. blood counts)
MPN - dec. counts
HbSS - increase HbF
What is the MOA of all-trans retinoids acid?
Binds one or more nuclear receptors and induces differentiation of APL cells
What is the indication of all-trans retinoic acid?
APL treatment
What is the MOA of Imatinib?
Binds and inhibits BCR-ABL tyrosine kinase
What is the indication for imatinib?
CML
What is another name for cobalamin?
Vitamin B12
What does desmopressin do?
Decreases bleeding by releasing factor VIII and vWF stored in endothelial cells into plasma
What do Fludabarine, Azacitidine, MTX, and hydroxyurea do?
Inhibit DNA synthesis
What do vinca alkaloids do?
Inhibit mitotic spindle
Which chemo drugs cause DNA damage by distorting the helix, and alkylation?
Anthracyclines (-rubicin drugs)
Alkylators (cyclophosphamide)
