MAO-B inhibitors

Question 1

name the 3 drugs in this class

Answer 1

• safinamide
• selegiline
• rasagiline

Question 1

interactions - increased risk of serotonin syndrome with…

Answer 1

• bupropion
• amphetamines
• isocarboxaid, phenelzine, trancylpromine (MAOIs)
• linezolid
• citalopram etc
• almotriptan etc
• methadone
• st johns wart
• tramadol

Question 2

interactions - adrenaline, ephedrine

Answer 2

increase risk of hypertensive crisis when given with MAO-B inhibitors
avoid

Question 3

interactions - increased risk of hypertensive crisis when given with the following drugs, avoid

Answer 3

• midrodrine
• methylphenidate, lisdexamfetamine, phenylephrine, psuedoephedrine

Question 4

interactions with B2 agonist

Answer 4

e.g. salbutamol, salmeterol etc

increase risk of severe hypertension when given with these drugs avoid.

Question 5

interaction with linezolid

Answer 5

increase risk of adverse effects when given with linezolid. avoid and for 14 days after stopping MAOI

Question 6

2 interactions with MAOIs

Answer 6

E.g. linezolid, trayncylpromine, phenelzine, isocarboxazid

MAO-Bi increase risk of adverse effects when given with these, avoid and for 14 days after stopping the MAOI

also increased risk of serotonin syndrome

Question 7

selegiline directions for administration - oral lyophilisates

Answer 7

should be placed on the tongue and allowed to dissolve. Advise patient not to drink, rinse, or wash mouth out for 5 minutes after taking the tablet.