Mechanism of Resistance

Question 1

____________ developed decreased entry to what two abx classes?

Answer 1

Pseudomonas developed decreased entry to fluoroquinolones (cipro, levo, moxi) and B-lactams (PCNs, Cephalosporins)

Question 2

_____________ developed altered target site to which drug class?

Answer 2

Pseudomonas developed altered target site to fluoroquinolones (cipro, levo, moxi)

Question 3

_____________ developed altered target site to which drug class?

Answer 3

MRSA developed altered target site to B-lactams

Question 4

________ developed enzymatic degradation to what drug class?

Answer 4

MSSA developed enzymatic degradation to B-Lactams (PCNs)

Question 5

_________ developed enzymatic degradation to _____________

Answer 5

MSSA developed enzymatic degradation to B-lactams (PCNS)

Question 6

MSSA makes __________ which breaks down penicillins (but not dicloxacillin, amox/clav or pip/tazo)

Answer 6

Penicillinase

Question 7

MSSA makes ___________ which breaks down penicillins

Answer 7

B-lactamase (so PCN not effective for MSSA)

Question 8

____________ developed a bypass pathway to ___________

Answer 8

Streptococci developed a bypass pathway to ____________

Question 9

__________ developed an efflux pump to which two drug classes?

Answer 9

-cocci developed an efflux pump to TCNs and MACs