Megaloblastic Anemia Flashcards Preview

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Flashcards in Megaloblastic Anemia Deck (4)
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1

Functions of folate

Synthesis of thymidylate from uridylate (dUMP to dTMP)
Synthesis of methionine from homocysteine
Synthesis of purines
Histidine catabolism

2

Earliest sign in vit b12 or folate deficiency detected before the onset of anemia

Macrocytosis

3

In severe anemia

Macrocytosis
Marked anisopoikilocytosis
Basophilic stippling
Howell-jolly bodies
Cabot’s ring

4

Megaloblastic anemia-White cells

Hypersegmentation-present when more than 5% neutrophils show 5 or more lobes