Messias TBL 2

Question 1

1st gen AP’s described as messy were known to be anti muscarinic causing:

Answer 1

Anticholinergic (dry mouth, blurry vis., constip.), histamine blockade, sedation, and weight gain

Question 2

Which AP is associated with agranulocytosis?

Answer 2

Clozapine

Question 3

Which drug is the only AP with proven efficacy for REFRACTORY schizophrenia?

Answer 3

Clozapine

Question 4

Decreased dopamine in what area of the brain is thought to produce the negative effects associated with schizophrenia?

Answer 4

Frontal Cortex

Question 5

Tuberoinfundibular pathway inhibits what hormones release?

Answer 5

Prolactin

Question 6

In schizophrenia how does the mesocortical pathway contribute?

Answer 6

Hypo activity for negative symptoms

Question 7

How does the mesolimbic pathway affect schizophrenia?

Answer 7

Hyperactivity leading to positive symptoms

Question 8

Which AP is most associated with “extrapyramidal sides” and EPS eliciting sides?

Answer 8

Haloperidol

Question 9

What are the common sides from 1st gen chlorpromazine?

Answer 9

Less eps, more sedation, hypotension, dry mouth, delirium.

Question 10

What is the recommended dose of respiridol? What enzyme breaks it down?

Answer 10

2-6 mg

2D6 isoenzyme

Question 11

What’s the therapeutic range for olanzapine? What breaks it down? What makes it metabolized faster?

Answer 11

10-20 mg

CYP1A2 (smoking)

Question 12

What’s the doc of patients with Parkinson’s that have associated psychotic symptoms from L-Dopa tx.?

Answer 12

Quetipine

Question 13

What two AP’s are known as “fast off” drugs?

Answer 13

Clozapine and quetipine

Question 14

Which AP is described as a partial agonist?

Answer 14

Apripriza

Question 15

Which AP can cause nausea from activating the CYZ?

Answer 15

Aripiprazole

Question 16

What’s the treatment of an ADS?

Answer 16

Intramuscular benztropine (cogent in) or diphenhydramine (Benadryl)

Question 17

What type of EPS is typically first to appear?

Answer 17

Acute dystonic reactions

Question 18

What is akathisia?

Answer 18

Inability to sit

Question 19

What’s the treatment for akathisia?

Answer 19

Propanol

Question 20

Which two drugs are at higher risk for akathisia?

Answer 20

Haloperidol and ariprazole

Question 21

What are the typical txs. for parkinsism?

Answer 21

Benztropine and trigexyphenidyl.

Amantadine

Question 22

In the short term with TD what are the efx. With 1) lowering the dose 2) raising the dose of AP

Answer 22

Lowering increases TD and vice versa

Question 23

What is the typical treatment for nms?

Answer 23

Immediate admittance to ICU with iv hydration

Question 24

What drug is used to reverse prolactemia?

Answer 24

Apriprazole

Question 25

Which drugs are associated with hyperprilactinemia

Answer 25

Haloperidol

Risoeridone and palioeridone

Question 26

Because of its strong affect on triglycerides which AP is a higher risk for coronary artery disease?

Answer 26

Quietepine

Question 27

What two drugs are at higher risk for weight gain and which two are lowest?

Answer 27

• clozapine and olanzapine

- Apriprazole and ziprasidone

Question 28

Name some lai’s:

Answer 28

TWO NAMES!!!!:

Haloperidol deconate, risperidone microspheres, olanzapine pamoate