Metabolism Flashcards

1
Q

hexokinase role

A

create G6P

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2
Q

what can inhibit PFK1

A

ATP
citrate

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3
Q

what stimulates PFK1

A

ADP
F2,6BP

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4
Q

aldolase creates what

A

G3P
DHAP

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5
Q

what converts DHAP to G3P

A

TPI (triose phosphate isomerase)

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6
Q

what creates 2 NADH in glycolysis

A

G3P dehydrogenase

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7
Q

what 2 enzymes generate ATP in glycolysis

A

phosphoglycerate kinase
pyruvate kinase

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8
Q

enolase forms what

A

PEP

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9
Q

pyruvate kinase role

A

convert PEP to pyruvate

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10
Q

what 2 enzymes in glycolysis use ATP

A

hexokinase
PFK1

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11
Q

4 substrates for gluconeogenesis

A

lactate
alanine
glutamine
glycerol

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12
Q

what converts lactate to pyruvate

A

lactate dehydrogenase

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13
Q

gluconeogenesis does not occur where

A

skeletal muscle (no G6 phosphatase)

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14
Q

pyruvate carboxylase role

A

convert pyruvate to oxaloacetate

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15
Q

MDH role

A

converts oxaloacetate to malate
(and the reverse)

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16
Q

what converts oxaloacetate to PEP

A

PEP carboxykinase

17
Q

what converts alanine to pyruvate

A

alanine transaminase

18
Q

where in the cell does gluconeogenesis occur?

A

mitochondria
cytosol
sER

19
Q

where is glucokinase

A

liver
beta cells

20
Q

hexokinase has high ___ and low ___

A

affinity
capacity

21
Q

glucokinase has a ___ affinity and ___ capacity

A

low
high

22
Q

___ inhibits glucokinase

A

F6P

23
Q

phosphoglucomutase role

A

convert G6P to G1P
(and the reverse)

24
Q

glycogen synthase creates what

A

a1,4

25
Q

rate limiting step of glycogenesis

A

glycogen synthase

26
Q

glycogen branching creates what

A

a1,6

27
Q

what oddly stimulates glycogen synthase

A

cortisol

28
Q

G6 phosphatase is only found where

A

liver