Metabolism Flashcards
1
Q
Phase I Reactions
A
Oxidations, Reductions, Hydrolysis
2
Q
Phase II Reactions
A
Conjugations
3
Q
Phase I Enzymes
A
CYP450, Reductases, Amidases
4
Q
Phase II Enzymes
A
Transferases
Glucuronidatio, Acetylation, GSH, Glycine, Sulfate
5
Q
DDIs
A
Phase I mostly
6
Q
Age Changes
A
Phase I mainly
7
Q
Saturability
A
Substantial w/ phase II
8
Q
Amidase vs. Esterase
A
Amidase has I in prefix. Esterase does not
9
Q
Inducers (PP CREST)
A
Phenobarbital Phenytoin Carbamazepine Rifampin Ethanol St John's Wort Tobacco Smoke
10
Q
Inhibitors (FACE HOG)
A
Fluoxetine Azole Antifungals Cimetidine Erythromycin/Clarithromycin HIV Protease Inhibitors Omeprazole Grapefruit Juice
