MHC Genetics

Question 1

T/F Polymorphism is due to gene rearrangement

Answer 1

FALSE

Question 2

What is polymorphism due to?

Answer 2

• amino acid variation

- multiple genes (DR)

Question 3

what is the HLA region?

Answer 3

region of chromosome which codes for the MHC?

Question 4

which classes of MHC genes share structural features?

Answer 4

class 1
class 2 alpha
class 2 beta

Question 5

What are the MHC class 2 isotypes?

Answer 5

DP
DQ
DR
Think: MHC Class 2 has 2 letters

Question 6

What are the MHC Class 1 isotypes?

Answer 6

A
C
B
E
F
G

Question 7

of the MHC class 1 isotypes, which are the most polymorphic?

Answer 7

A, B, C;

present to CD8 T cells, ligands for NK cells

Question 8

What does the MHC Class 2 isotypes present to?

Answer 8

DP, DQ, DR present to CD4 T cells

Question 9

what region of the chromosome is responsible for the MHC Class 1 and 2 determination?

Answer 9

HLA locus

Question 10

what is the HLA allele associated with Ankylosiing spondylitis?

Answer 10

B27

Question 11

what is the HLA allele associated with multiple sclerosis?

Answer 11

DR2

Question 12

what is linkage disequilibrium?

Answer 12

the situation when particular alleles of two or more polymorphic genes are inherited together at frequencies higher than expected by chance

Question 13

what is the haplotype?

Answer 13

…

Question 14

what is the genotype?

Answer 14

…

Question 15

People heterozygous for DQ2 and DQ8 are most susceptible to what condition?

Answer 15

IDDM

Question 16

T/F We get phenotype first and then determine genotype

Answer 16

TRUE