Micro-organisms Pathologies & Tropisms Flashcards Preview

IHO Week 1 > Micro-organisms Pathologies & Tropisms > Flashcards

Flashcards in Micro-organisms Pathologies & Tropisms Deck (19):
1

Pathology of CTFV:

-Saddleback fever pattern
-Travel to mountain West

2

Pathology of CMV (HHV-5)?

-CMV infectious mononucleosis
-Heterophile Ab negative
-Owl's eyes cells
-Congenital systemic CMV - deafness

3

Pathology of HHV-6 & 7?

-Exanthem subitum (aka roseola), rash that develops after a fever resolves
-Heterophile Ab negative mononucleosis

4

Pathology of EBV (HHV-4)?

EBV infectious mononucleosis
-Heterophile Ab positive mono
-Burkitt lymphoma: t(8:14)
Hodgkin & non-Hodgkin lymphoma
-Nasopharyngeal lymphom
-X-linked lymphoproliferative disease
-Inherited mutation in SAP adapter

5

Pathology of Kaposi sarcoma herpes virus (HHV-8)?

In immunocompromised only
-Kaposi sarcoma
-Primary effusion lymphoma
-Multifocal Castlemans disease

6

Pathology of Parvovirus B19?

Erythema infectiosum - Fiery red rash on cheek (slapped cheek), transient aplastic crisis in patients with underlying anemia

7

HTLV-1 and HTLV-2 pathology?

Acute T cell lymphoma (ATL)
-Viral transcription factor Tax drives proliferation; blocks apoptosis
-HAM/TSP - Inflammation of the spine

8

HIV-1 and HIV-2 pathology?

Acquired immunodeficiency syndrome: depletion of CD4 T cells allows opportunistic infections

9

Ebola pathology?

Hemorrhagic fever

10

Tropism for Ebola?

Macrophages

11

Tropism for HIV-1, HIV-2?

CD4+ T cells (also CD4+ monocytes & macrophages & others)

12

Tropism for HTLV-1, HTLV-2?

T cells (1 - Greater CD4+, 2 - Greater CD8+)

13

Tropism for Parvovirus B19?

Erythroid progenitor cells!

14

Tropism for Kaposi Sarcoma (KSHV, HHV-8)?

In immunocompromised patients only, Kaposi sarcoma, primary effusion lymphoma, multifocal Cattleman's disease

15

Tropism for Kaposi Sarcoma (KSHV, HHV-8)?

Epithelial Cells, B cells

16

Tropism for EBV?

Acute: epithelial cells of oropharynx (supports lytic life cycle), Latent: B cells

17

Tropism for HHV-6 & 7?

CD4+ T cells, PBMNCs, epithelial cells

18

Tropism for Cytomegalovirus?

Systemic
-Latent in CD34+ cells (monocyte --> macrophage)

19

Tropism for CTFV?

Pro-erythroblasts --> mature RBCs