Microbial Drugs

Question 1

Drug(s) that injure Plasma Membrane

Answer 1

Miconazole (antifungal drug)

Question 2

Miconazole:

Target and MofA

Answer 2

Targets: an enzyme needed for ergosterol synthesis

MofA: Ergosterol is a type of steroid that fungi use to put on their plasma membrane; It gives their cell membrane rigidness. Because ergosterol can’t be synthesized anymore, the plasma membrane of fungi loses its integrity and becomes too fluid overtime/becomes weak.

Question 3

Inhibitors of DNA Replication and

MofA

Answer 3

Fluoroquinolones

Inhibit bacterial enzymes that help uncoils DNA during replication

Question 4

Inhibitors of transcription/RNA Polymerase and

MofA

Answer 4

Rifampin
This drug inhibits the active site of RNA polymerase. As a result transcription is stopped. mRNA isn’t synthesized and therefore no needed products (proteins) are made.

Question 5

Name two disadvantages of natural Penicillin G and Penicillin V

Answer 5

They have narrow spectrum activity and are susceptible to B-lactamase

Question 6

B-lactamase effective against (it will work)

Answer 6

Amoxicillin, Penicillin G, Penicillin V

Question 7

Narrow Spectrum Drugs

Answer 7

Penicillin G, Penicillin V, Vancomycin

Question 8

Broad Spectrum Drugs

Answer 8

Methicillin, Cephalosporin, Amoxicillin

Fluroquinolones, Rifampin, Streptomycin, Tetracycline, Chloramphenical, Eurythromycin

Question 9

Inhibtis gene expression

Answer 9

Rifampin, streptomycin, chloramphenicol, tetracycline, erythromycin

Question 10

Toxicity concerns

Answer 10

All ribosome inhibitors (streptomycin, tetracycline, chloramphenicol, erythromycin)
and Fluoroquinolones

Question 11

Not effective orally

Answer 11

vancomycin, penicillin G

Question 12

Targets peptidoglycan

Answer 12

All penicillins (Amoxicillin, Methicillin, Penicillin G and V)
Cephalosporin, Vancomycin

Question 13

Anti-fungal

Answer 13

Miconazole

Question 14

Inhibits DNA synthesis

Answer 14

Fluoroquinolones