Mitosis/Miosis Flashcards
1
Q
How does a cell prevent re-replication of DNA?
A
M- high CDK prevents building Pre-Replication Complex
G1- low CDK allows building of Pre-RC
S- high CDK activates replication and prevents any more Pre-RC building
During G1, ORC (origin of replication complex) proteins
2
Q
ATM and ATR are important for cell checkpoint regulation. Patients with defects in ATM gene (Ataxia Telangiectasia Mutated) develop what?
A
Cancer and neurological defects.
3
Q
Patients with familial histories of female cancers likely have mutations in which genes?
A
BRCA1 and BRCA2.
4
Q
What do BRCA1 and BRCA2 normally do?
A
They regulate the ATM/ATR pathway.
The boobs regulate the money (ATM)
