MOA - all

Question 1

cephalosporin, penicillin

Answer 1

inhibits cross linking of peptidoglycan in the cell wall

Question 2

macrolides (erythromycin, clindamycin, azithromycin)

Answer 2

binds to 50S; bacteriostatic

Question 3

fluoroquinolone (levaquin)

Answer 3

blocks topoisomerase II which mainly targets gram negative bacteria

Question 4

• azole drugs

Answer 4

blocks 14 alpha demethylase

Question 5

terbinafine

Answer 5

down regulates squalene epoxidase

Question 6

amphotericin + nystatin

Answer 6

binds to ergosterol and creates pores to create cell instability and death

Question 7

caspofungin/micafungin/anidulafungin

Answer 7

targets 1,3 beta D-glucan synthase

SE -facial swelling, increase AlkPhos, hypokalemia, and hematuria/proteinuria (**2/2 to caspofungin use only)

Question 8

terbinafine and griseofulvin ae NOT useful in what kind of disease?

Answer 8

candidal infection (only dermatophytosis)

**these also cause drug induced SCLE

Question 9

tetracycline

Answer 9

binds to 30S

Question 10

Rifampin

Answer 10

inhibits bacterial RNA polymerase

Question 11

cyclosporine

Answer 11

calcinuerin inhibitor though binding of cyclophilin

Question 12

tacrolimus

Answer 12

calcineurin inhibitor through binding of FDBP122 (FK506 binding protein)

Question 13

Azathioprine

Answer 13

purine analog that blocks S phase

Question 14

sirolimus (rapamycin)

Answer 14

mTOR inhibitor

Question 15

CellCept (mycophenolate mofetil)

Answer 15

IMP dehydrogenase inhibitor

Question 16

cyclophosphamide

Answer 16

cross linking of DNA and RNA and inhibition of protein synthesis; this is an alkylating agent of nitrogen mustard

Question 17

vancomycin

Answer 17

inhibits cell wall synthesizes by binding to D-Ala-D-Ala

Question 18

mupirocin

Answer 18

works by binding to isoleucyl tRNA synthetase

Question 19

retapamulin (altabax)

Answer 19

binds to L3 protein on 50S

Question 20

neosporin

Answer 20

made up of bacitracin (gram +), polymyxin (gram -), and neomycin (both)

Question 21

5 FU (Efudex)

Answer 21

blocks thymidylate synthetase

Question 22

imiquimod (aldara)

Answer 22

blocks TLR 7

**has been a/w milia, EIC, psoriasis, and vitiligo

Question 23

PDT

Answer 23

uses ALA to produce protoporphyrin IX metabolites within the cell

Question 24

infliximab (Remicade)

Answer 24

TNF alpha inhibitor; chimeric monoclonal Ab

Question 25

adalimumab (Humira)

Answer 25

TNF alpha inhibitor; human monoclonal Ab

Question 26

etanercept (Enbrel)

Answer 26

TNF alpha inhibitor; fusion protein

Question 27

dupixent (dupilumab)

Answer 27

blocks IL-4, IL-13

Question 28

GRUT - blocks IL-23

Answer 28

Tremfya, Skyrizi, Stelara (*blocks IL12/23), Ilumya

Question 29

SIB - blocks IL-17

Answer 29

Cosentyx, Taltz, Siliq (depression SE)

Must review for IBD

Question 30

omalizumab (Xolair)

Answer 30

block IgE

Question 31

Otezla (apremilast)

Answer 31

PDE 4 inhibitor

Question 32

Otezla (apremilast)

Answer 32

PDE 4 inhibitor

Question 33

methotrexate

Answer 33

inhibits DHF reductase; purine and pyrimidine synthesis

Question 34

dapsone

Answer 34

competes with PABA inhibiting folic acid synthesis

Question 35

griseofulvin and podophyllin

Answer 35

prevents mitosis by binding to the protein tubular and preventing microtubule formation and cell division

do NOT use podophyllin in pregancy. Use: genital warts

griseofulvin can instigate or worsen porphyria and/or lupus

Question 36

ciclopirox

Answer 36

binds to cation-dependent enzymes necessary for fungal cell wall function