MoA Of Drugs

Question 1

What is the mode of action of acyclovir?

Answer 1

Acyclovir is a prodrug which gets phosphorylised and then either inhibits the DNA polymerase OR acts as a nucleide chain blocker as it does not possess an OH on 3’ which breaks the phosphate chain.

Question 2

What is the action of delaviridine?

Answer 2

They have a different structure to nucleotides and they exert direct, allosteric inhibition of DNA polymerase. No need to be phosphorylated to be active

Question 3

How are protides better than acyclovir?

Answer 3

They skip the rate limiting step by having their first phosphate already, protects liable phosphate from cleavage due to steric hinderance, after activation releases nontoxic products.

Question 4

What is the MoA of Warfarin

Answer 4

Inhibits vitamin K reductase which is a key factor in coagulation

Question 5

What is the MoA of Flecainide?

Answer 5

Na+ and K+ channel blocker in the heart which raises the threshold for depolarisation hopefully fixing the arrhythmia, class 1 antiarrhymthia drug.

Question 6

What is the MoA of