Module 7: Malignant leukocyte disorders

Question 1

Most prevalent malignant leukocyte disorder in children

Answer 1

Acute lymphoblastic leukemia

Question 2

WHO classification for malignant leukocyte disorders

Answer 2

World Health Organization
- uses all available information to classify, including morphology, cytochemical staining, immunophenotype, genetics and clinical features

Question 3

FAB system for classification of malignant leukocyte disorders

Answer 3

French-American-British

- Based on morphological characteristics

Question 4

Which leukemia has the highest prevalence of smudge cells?

Answer 4

Chronic lymphocytic leukemia (CLL)

Question 5

Cell present in Hodgkin’s lymphoma

Answer 5

Reed-Sternberg

Question 6

RARS

Answer 6

Refractory anemia with ringed sideroblasts

Question 7

LAP stain is used to differentiate:

Answer 7

CML (LAP decreased) and leukemoid reaction

100 cells counted and scored

Question 8

Most common AML

Answer 8

M2

Question 9

Rarest AML

Answer 9

M7

Question 10

Cells that are TRAP positive

Answer 10

Hairy cells and Sezary cells

Question 11

Which AML is associated with DIC and why?

Answer 11

M3 because it has hypergranular promyelocytes, and the thromboplastin substance in granules induces clotting

Question 12

In which disorder will we see Sezary cells?

Answer 12

Non-Hodgkin’s lymphoma

Question 13

If multiple Auer rods are present, what is the most likely type of AML present?

Answer 13

M3

Question 14

20% of patients get AIHA with spherocytes (which disorder?)

Answer 14

Chronic lymphocytic leukemia (CLL)

Question 15

What disorder might we suspect if we see anemia, rouleaux, plasma cells, and a blue background in a PBS?

Answer 15

Multiple myeloma

Question 16

FAB classification of Burkitt’s lymphoma

Answer 16

L3

Question 17

Cell appearance in Burkitt’s lymphoma (L3)

Answer 17

Vacuolated

Question 18

AML most associated with erythroblasts

Answer 18

M6 - DiGuglielmo syndrome

Question 19

4 types of chronic myeloproliferative disorders

Answer 19

Polycythemia rubria vera
Chronic idiopathic myelofibrosis
Essential thrombocytosis
Chronic myelogenous leukemia

Question 20

Another name for Schilling’s leukemia

Answer 20

M5

Question 21

Another name for M5

Answer 21

Schilling’s leukemia

Question 22

Another name for DiGuglielmo syndrome

Answer 22

M6

Question 23

Another name for M6

Answer 23

DiGuglielmo syndrome

Question 24

In which MDS might we see Auer rods?

Answer 24

RAEB-2

Question 25

Myelophthisic anemia

Answer 25

Developing erythroid cells in the bone marrow are crowded out due to infiltration of the bone marrow (with fibrin, malignant cells, etc.), leading to a severe anemia