Module F Flashcards
Ventromedial Hypothalamus
Satiety center - decrease in feeding behavior *glucose/leptin = regulate satiety
Lateral Hypothalamus
Increase in feeding behavior
Ventromedial Hypothalamic Syndrome (Frohlich Syndrome)
Cause: damage to ventromedial nucleus of hypothalamus
ROS: obesity due to caloric imbalance
Diabetes Insipidus
Cause: insufficiency of supraoptic n. of hypothalamus
ROS: absence of ADH inducing excessive thirst (polydypsia) and polyuria
Hypothermia
Lesion of posterior hypothalamus
Hyperthermia
Anterior hypothalamus lesion
Horner’s Syndrome
Cause: PICA syndrome, pancoast tumor, lesion of hypothalamospinal pathway ROS: miosis, anhydrosis, ptosis
Automatic Bladder
Cause: suprasacral spinal transection
ROS: pt will not have sensory signals conveyed to cortex so bladder fills to a threshold in pressure is reached then there is spontaneous (automatic) emptying
Atonic bladder
Cause: lesion to midsacral efferent/afferent (e.g. - conus medullaris) interrupting urinary reflex arc
ROS: sensation of bladder fullness is lost and pt will be unable to contract detrusor (PsNS) for micturition
Jet Lag (Desynchronosis)
Mismatch of circadian clock w/ light/dark stimuli
ROS: insomnia and daytime sleepiness
*worse from West –> East
Seasonal Affective Disorder (SAD)
Symptoms begin in autumn and remit in spring, persons @ high altitudes corresponding to lengthened dark periods
ROS: changes in mood and sleep patterns
Narcolepsy
Hypnogram: rapid onset of REM sleep
ROS: cataplexy (sleep paralysis), usually triggered by heightened emotions
Tx: Modafinil - modulates central dopaminergic pathways
Periaqueductal gray
Pain modulation
increased prolactin after TBI
Dopamine has inhibitory effect on lactotrophes, so increased prolactin levels after TBI would indicate possible injury of infundibulum of pituitary
Hypothalamus + Posterior Pituitary
SAD - POX Suprachiasmatic nucleus: ADH Paraventricular nucleus: oxytocin
Anterior Hypothalamus
Decreases body temp
Posterior Hypothalamus
Increases body temp
Adrenal Medulla (SNS)
Modified post-ganglionic (2nd order) sympathetic neuron
Hirschprung’s Dz (Megacolon)
Absence of myenteric plexus and submucosal plexuses in GI ROS: deficient motility/peristalsis
Complex Regional Pain Syndrome (CRPS)
increased output or sensitization of nociceptors to NE ROS: chronic pain following injury
Atenelol
Beta-1 antagonist Tx: HTN