Movement disorders - Multiple Sclerosis Flashcards by anu pokharel | Brainscape

Q

Main point of drugs

A

inhibit the immune response

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Q

Actions of Immunomodulators

A

shift: pro- to anti-inflammatory
dec T cell prolif
inh T cell migration
Reduces BBB breakdown

IFN - beta 1a or 1b

Binds T-cell VLA-4 ( prevent BBB adhesion)

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Q

ADR of immunomodulators

A

Flu-like sx
HA
pain
Depression
ALT and AST inc
UTI
inj site discomfort

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Q

Used for worsening RRMS

A

Mitoxantrone

IV fusion every 3 months

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Q

Natiluzumab

A

reduces new lesions and size

its a monoclonal Abs (alpha-4 integrins)

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Q

ADR of natiluzumab

A

multifocal leukoencephalopathy

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Q

First choice in acute relapse

A

Methylprednisolone

tightens BBB
Suppress immune response

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Q

Helps ptns with severe spasticity

A

Baclofen

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