mt.1 Antigen Antibody Lec 6 (IgG) Flashcards
Where are isotypic differences located?
within the constant regions of the heavy chain
*IgG, A, M, E, D
Where are allotypic differences located?
within some portion of Fc region
- **doesn’t affect binding to antigen
- IgG from one person may be different than IgG from another person within Fc
Where are idiotypic differences located?
Differences are with the Fab region
- **variable regions
- IgG from one immune response to antigen A is different than IgG from another immune response to antigen B and etc
Five Immunoglobulin classes of antibody based on heavy chain constant region
Y heavy chain= IgG class alpha haeavy chain= IgA class U heavy chain = IgM class epsilon HC= IgE sigma HC= IgD class
What are the two classes of lights chains?
Kappa
Lambda
T/F… any individual immunoglobulin molecule will have kappa or lambda
TRUE. They will have one OR the other. THEY WILL NOT HAVE BOTH
T/F… any population of immunoglobulins will have both kappa and lambda represented
TRUE. every population will have both light chains represented, but individual immunoglobulins will have one or the other
T/F… Each immunoglobulin isotype is identical
FALSE
*Each immunoglobulin isotype has distinctive features
What immunoglobulin has the highest concentration in blood?
IgG
IgG heavy chains have how many domains?
4 (one variable, 3 constant)
IgG heavy chains is how big?
150,000 daltons mw
What are the sub classes of IgG?
four sub-classes: IgG1, IgG2, IgG3, IgG4
Most sub-classes of IgG are able to fix ____, cross the _____, and enhance ______?
fix complement
cross placenta
enhance phagocytosis (opsonization)
complement fixation requires the _____ domains?
Fc domains
IgG antibodies are good at opsonization, this means?
enhancement of phagocytosis
