Multiple Endocrine Neoplasia Flashcards by Ben Subhani | Brainscape

Q

What is the cause of MEN type I

A

MEN 1 gene mutation

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Q

What is the cause of MEN type IIa

A

RET oncogene mutation

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Q

What is the cause of MEN type IIb

A

RET oncogene mutation

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Q

What are the clinical features of MEN type I

A

Most common presentation is Hypercalcaemia

3 P’s

Parathyroid 95% (raised due to hyperplasia)
Pituitary 70% (tumours)
Pancreas 50% (tumours)

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Q

What are the clinical features of MEN type IIa

A

Can get hypercalcaemia

Medullary Thyroid cancer (70%)

2 P’s

Parathyroid (60%)
Phaeochromocytoma

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Q

What are the clinical features of MEN type IIb

A

Medullary Thyroid cancer

1 P
- Phaeochromocytoma

Marfanoid body habitus

Neuroma

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