Muscle Relaxants Flashcards
What is Dibucaine Number?
Percentage of inhibition of Pseudocholinesterase by Dibucaine(a local anaesthetic)
How will you managed prolonged NM blockade d/t reduced concentration or function of Pseudocholinesterase?
Transfuse Fresh frozen Plasma. Continue Mechanical Ventilation until patient recovers.
What is the induction dose of Scoline?
IV - 0.5-2mg/kg
onset - 30-90secs
DOA - 5-10mins
t1/2 - 2-4mins
IM - 2.5mg/kg
What are the Side effects of Scoline?
- Increased ICT (c/b avoided by NMDA pre rx)
- Increased IOP (c/b avoided by NMDA pre rx)
- Arrythmias - Sinus Bradycardia, Junctional Rythms, Ventricular arrythmias
- Masseter Spasm- m/c in children
- Increased IGP - Significance in Hiatus Hernia, Intust obstruction etc –> to prevent aspiration of gastric contents
- Muscle pain
- HYPERKALEMIA - increase by 0.5 meq/ml
What are the Long acting NDMR?
Pancuronium
Doxacurium
dTC
Gallamine
What are the Intermediate acting NDMR?
Vecuronium
Atracurium
Cis-atracurium
Rocuronium
What are the short acting NMDR?
Mivacurium
What are the Steroidal compounds in NDMR?
Pancuronium
Vecuronium
Rocuronium
Pipecuronium
High potency, lacks histamine release, vagolytic, excreted by Kidneys
What are the Benzylisoquinolium compounds in NDMR?
Atracurium
Cisatracurium
Mivacurium
Doxacurium
dTC
Metocurine
High potency, tendency to cause histamine release except cisatracurium and doxacurium, lack of vagolytic property
What are the Phenolic ether in NMDR?
Gallamine
Long acting, strong vagolytic, excreted unchanged via kidneys
What are the Strychnos alkaloid NMDR?
Alcuronium
Long acting, weakly vagolytic, lacks histamine release
What is the dose for Chemically mediated histamine release for Atracurium & Mivacurium?
Atracurium - 0.5mg/kg
Mivacurium - 0.2mg/kg
