Na/K ATPase

Question 1

What is Na/K ATPase?

Answer 1

Na/K ATPase is a heterodimer composed of an alpha subunit (catalytic) and a beta subunit (stability). Its function is Na+ reabsorption into the kidneys and it does this by an intake of 2K+ ions and an extrusion of 3 Na+ ions.

Question 2

Acute regulation of Na/K ATPase and Chronic regulation of Na/K ATPase

Answer 2

Acute regulation refers to the number of Na/K ATPase subunits on the basolateral surface and the phosphorylation of the Na/K ATPase. Chronic regulation refers to the gene expression levels of the Na/K ATPase and total cellular levels of Na/K ATPase.

Question 3

Cellular location of the Na/K ATPase

Answer 3

In polarized cells, the Na/K ATPase is localized to the basolateral surface.

Question 4

What is Na/H antiport system?

Answer 4

This is a transmembrane protein localized to the apical surface of polarized cells and allows Na+ ions to enter the cell.

Question 5

Natriuresis

Answer 5

Excretion of sodium into the urine

Question 6

Diuresis

Answer 6

Increased production of urine