Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Functional Human Neuroanatomy > Name The Lesion > Flashcards

Name The Lesion Flashcards

Clinical correlates and functional areas

1
Q

Symptom:

Dizziness (vertigo), nausea

A

Vertebrobasilar Ischemia:

Vestibular nuclei, cerebellum or inner ear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Symptom:

Diplopia, dyscongugate gaze

A

Vertebrobasilar Ischemia:

Supranuclear or infranuclear eye movement pathways

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Symtom:

Blurred vision or other visual disturbances

A

Vertebrobasilar Ischemia:

Eye movement pathways or visual cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Symptom:

Incoordination (ataxia)

A

Vertebrobasilar Ischemia:

Cerebellum or cerebellar pathways

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Symptom:

Unsteady gait

A

Vertebrobasilar Ischemia:

Cerebellar pathways; long sensory or motor tracts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Symtom:

Dysarthria, Dysphagia

A

Vertebrobasilar Ischemia:

Corticobulbar pathways or brainstem cranial nerve nuclei

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Symptom:

Numbness and tingling, particularly bilateral or perioral

A

Vertebrobasilar Ischemia:

Long somatosensory pathways or trigeminal system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Symptom:

Hemiparesis, quadriparesis

A

Vertebrobasilar Ischemia:

Corticospinal tract

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Symptom:

Somnolence

A

Vertebrobasilar Ischemia:

Pontomesencephalic reticular formation or bilateral thalami

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Symptom:

Headache at occipital region

A

Vertebrobasilar Ischemia:

Posterior fossa meninges and vessels (CN X and cervical roots)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Symptom:

Headache at frontal region

A

Vertebrobasilar Ischemia:

Supratentorial meninges and vessels (CN V; PCA is often CN V1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Symptom:

Nonlocalized/diffuse headache

A

Vertebrobasilar Ischemia:

Supra- and/or infratentorial meninges and vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Midbrain Vascular Supply (Level 3) @ Superior Colliculus

A

SCA and proximal PCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Midbrain Vascular Supply (Level 3) @ ML, STT, Red Nucleus, Substantia Nigra, Oculomotor Nucleus + EW Nucleus

A

Paramedian branches at top basilar artery (interpeduncular fossa)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Midbrain Vascular Supply (Level 3) @ Cerebral Pedunces, CST, CBT

A

Proximal PCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Focal Vascular Syndrome to Midbrain basis

A

Name: Webers Syndrome

Vascular Supply: Branches of PCA + Top of Basilar Artery

Structures:

  • Oculomotor nerve fascicles
  • Cerebral Peduncles

Anatomical Clinical Feature(s):

  • Ipsilateral third-nerve palsy
  • Contralateral hemiparesis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Focal Vascular Syndrome to Midbrain tegmentum

A

Name: Claudes Syndrome

Vascular Supply: Branches of PCA + Top of Basilar Artery

Structures:

  • Oculomotor nerve fascicles
  • Red nucleus, superior cerebellar peduncle fibers

Anatomical Clinical Feature(s):

  • Ipsilateral third-nerve palsy
  • Contralateral ataxia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Focal Vascular Syndrome to Midbrain basis and tegmentum

A

Name: Benedikt’s syndrome

Vascular Supply: Branches of PCA + Top of Basilar Artery

Structures:

  • Oculomotor nerve fascicles
  • Cerebral peduncle
  • Red nucleus, substantia nigra, superior cerebellar peduncle fibers

Anatomical Clinical Feature(s):

  • Ipsilateral third-nerve palsy
  • Contralateral hemiparesis
  • Contralateral ataxia, tremor and involuntary movements
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Rostral Pons Vascular Supply (Level 5) @ Superior Cerebellar peduncle

A

Superior Cerebellar Artery (SCA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Rostral Pons Vascular Supply (Level 5) @ Reticular formation, Trigeminal nerve, Middle cerebellar penduncle, STT, ML

A

Basilar artery (circumferential branches = lateral pontine arteries)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Rostral Pons Vascular Supply (Level 5) @ Pyramidal tract or CST and CBT, ML, reticular formation

A

Basilar artery (paramedian branches)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Caudal Pons Vascular Supply (Level 6/7) @ Vestibular nuclei, facial nucleus and nerve vascicles, spinal trigeminal nucleus and tract, middle cerebellar peduncle, STT, descending sympathetic fibers

A

AICA and basilar artery (circumferential branches = lateral pontine arteries)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Caudal Pons Vascular Supply (Level 6/7) @ abducens nucleus, MLF, ML, pontine nuclei, pyramidal tract or CST and CBT

A

Basilar artery (paramedian branches)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Focal Vascular Syndrome to Medial pontine basis (rostral and caudal levels)

A

Name:

  • Dysarthria Hemiparesis (pure motor hemiparesis)
  • Ataxic Hemiparesis

Vascular Supply:
-Paramedian branches of basilar artery, ventral territory

Structures:

  • Corticospinal and corticobulbar tracts
  • Pontine nuclei and pontocerebellar fibers

Anatomical Clinical Features:

  • Contralateral face, arm, leg weakness; dysarthria
  • Contralateral ataxia (occassionally, ipsilateral ataxia)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Focal Vascular Syndrome to Lateral Caudal Pons

A

Name:
-AICA Syndrome

Vascular Supply:
-AICA

Structures:

  • Middle Cerebellar Peduncle
  • Vestibular nuclei
  • Spinal trigeminal nucleus and tract
  • STT
  • Descending sympathetic fibers

Anatomical Clinical Features:

  • Ipsilateral ataxia
  • Vertigo, nystagmus
  • Ipsilateral facial decreased pain and temperature sense
  • Contralateral body decreased pain and temperature sense
  • Ipsilateral Horner’s syndrome
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Focal Vascular Syndrome to Dorsolateral rostral pons

A

Name:
-SCA syndrome

Vascular Supply:
-SCA

Structures:

  • Superior Cerebellar Peduncle and Cerebellum
  • Other lateral tegmental structure (variable)

Anatomical Clinical Features:

  • Ipsilateral ataxia
  • Variable features of lateral tegmental involvement (like AICA syndrome)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Focal Vascular Syndrome to Medial pontine basis and tegmentum @ Level 6/7 or Caudal Pons

Damage to corticospinal and corticobulbar tracts

A

Name: Foville’s syndrome

Vascular Supply: Paramedian branches of basilar artery, ventral and dorsal territories

Anatomical Clinical Features: Contralateral face, arm, and leg weakness; dysarthria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Focal Vascular Syndrome to Medial pontine basis and tegmentum @ Level 6/7 or Caudal Pons

Damage to facial colliculus

A

Name: Foville’s syndrome

Vascular Supply: Paramedian branches of basilar artery, ventral and dorsal territories

Anatomical Clinical Features:

  • Ipsilateral face weakness (CN 7 nucleus and fasciles right there)
  • Ipsilateral horizontal gaze palsy (CN 6 abducens nucleus right there)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Focal Vascular Syndrome to Medial pontine basis and tegmentum @ Level 6/7 or Caudal Pons

Damage to abducens nucleus or paramedian pontine reticular formation (PPRF)

A

Name: Pontine wrong-way eyes

Vascular Supply: Paramedian branches of basilar artery, ventral and dorsal territories

Anatomical Clinical Features:

  • Ipsilateral horizontal gaze palsy (CN 6 abducens nucleus right there)
  • Typically comes along with contralateral face, arm, and leg weakness and eyes look TOWARD side of weakness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Focal Vascular Syndrome to Medial pontine basis and tegmentum @ Level 6/7 or Caudal Pons

Damage to fascicles of facial nerve

A

Name: Millard-Gubler Syndrome

Vascular Supply: Paramedian branches of basilar artery, ventral and dorsal territories

Anatomical Clinical Features:

  • Ipsilateral face weakness
  • Typically comes along with contralateral face, arm, and leg weakness secondary to CST/CBT deficit
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Focal Vascular Syndrome to Medial pontine basis and tegmentum @ Level 6/7 or Caudal Pons

Damage to Medial Lemniscus

A

Vascular Supply: Paramedian branches of basilar artery, ventral and dorsal territories

Anatomical Clinical Features:
-Contralateral decreased position and vibration sense

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Focal Vascular Syndrome to Medial pontine basis and tegmentum @ Level 6/7 or Caudal Pons

Damage to Medial Longitudinal Fasciculus (MLF)

A

Vascular Supply: Paramedian branches of basilar artery, ventral and dorsal territories

Anatomical Clinical Features:
-Internuclear ophtalmoplegia (INO)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Internuclear ophtalmoplegia (INO)

A

Disorder of conjugate lateral or horizontal gaze secondary to lesion of MLF. Affected individuals have slowed or limited idduction in the eye IPSILATERAL to the lesion, with associated abducting nystagmus in the contralateral eye.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Medullary Vascular Supply (Level 10/12) @ ML, Pyramidal tract, fascicles of hypoglassal nerve and hypoglassal nucleus

A

Vertebral artery (paramedian branches) and anterior spinal artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Medullary Vascular Supply (Level 10/12) @ inferior olivary nucleus

A

Vertebral artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Medullary Vascular Supply (Level 10/12) @ Inferior cerebellar peduncle, solitary nucleus and tract, NA, fascicles of vagus nerve, Spinal trigememinal nucleus and tract, STT, dorsal efferent nucleus of vagus, descending sympathetic fibers

A

Vertebral artery and PICA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Focal Vascular Syndrome to Medial Medulla

A

Name: Dejerine Syndrome (medial medullary syndrome_

Vascular Supply: Paramedian branches of vertebral artery and anterior spinal arteries

Structures:

  • Pyramidal tract
  • Medial lemniscus
  • Hypoglossal nucleus and exiting CN XII fascicles

Anatomical Clinical Features:

  • Contralateral arm or leg weakness
  • Contralateral decreased position and vibration sense
  • Ipsilateral tongue weakness
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Focal Vascular Syndrome to Lateral Medulla

A

Name: Wallenberg’s syndrome (lateral medullary syndrome)

Vascular Supply: vertebral artery and anterior spinal arteries (more commonly than PICA)

Structures:

  • Inferior Cerebellar peduncle, vestibular nuclei
  • Spinal trigeminal nucleus and tract
  • Spinothalamic tract
  • Descending sympathetic fibers
  • Nucleus ambiguus
  • Nucleus solitarus

Anatomical Clinical Features:

  • Ipsilateral ataxia, vertigo, nystagmus, nausea
  • Ipsilateral facial decreased pain and temperature sense
  • Contralateral body decreased pain and temperature sense
  • Ipsilateral Horners syndrome
  • Horseness, dysphagia
  • Ipsilateral decreased taste
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Horners Syndrome

A

Horner’s syndrome is a rare condition characterized by miosis (constriction of the pupil), ptosis (drooping of the upper eyelid), and anhidrosis (absence of sweating of one side of the face). It is caused by damage to the sympathetic nerves of the face.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Vascular Supply to Cerebellum: Top portion of vermis, superior zones on both dorsal and ventral sides

A

SCA territory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Vascular Supply to Cerebellum: SCP, MCP, ICP, flocculus with surrounding medial zones, very small portion of lateral hemispheres at farthest aspect on dorsal side

A

AICA territory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Vascular Supply to Cerebellum: Bottom portion of vermis, inferior zones on both dorsal and ventral sides including the nodulus

A

PICA territory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Vascular Supply to Forebrain: Along interhemispheric fissure, medial frontal lobe anterior to the preccentral gyrus, most of corpus callosum anteriorly, anterior cingulate gyrus

A

Anterior Cerebral Artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

ACA Key Functional Areas

A
  • septal area
  • anterior cingulate gyrus (limbic system -related cortex)
  • primary motor cortex for the leg and foot areas, and the medial frontal micturition center
  • additional motor planning areas in the medial frontal lobe, anterior to the precentral gryus
  • primary somatosensory cortex for the leg and foot
  • most of the corpus callosum except its posterior part.
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Vascular Supply to Forebrain: Temporal-frontal areas surrounding lateral sylvian fissure, regions of BG and anternal capsule

A

Middle Cerebral Artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Superior Cortical MCA Key Functional Areas

A

-Primary motor cortex for face and arm, and axons originating in the leg as well as face and arm areas that are traveling in the deep white matter toward the internal capsule as part of the corticobular or corticospinal tracts
-Broca’s area and other related gray and white matter important for language
expression – in the language-dominant (usually L) hemisphere
-Frontal eye fields (important for ‘looking at’ eye movements to the opposite side)
-Primary somatosensory cortex for face and arm (But be aware that this cortex and
even the primary motor cortex can be supplied by inferior branches in some people)
-Parts of lateral frontal and parietal lobes important for lateralized attention
(perceptions of one’s own body and of the outside world), visuospatial analysis, and
for expressing emotions with the voice and body language in the R hemisphere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Inferior Cortical MCA Key Functional Areas

A

-Wernicke’s and other related areas important for language comprehension in the
language- dominant (usually L) hemisphere
-Parts of the lateral parietal and temporal lobe important for lateralized attention, and
visuospatial analysis, and for the ability to interpret emotions in the voices and body
language of others – in the R hemisphere
-primary somatosensory cortex, and sometimes also part of the primary motor cortex
-Optic radiations. Axons that carry information about the contralateral superior
quadrants of the visual fields loop forward into the temporal lobe (they are located anterior and lateral to the temporal horn of the lateral ventricle). Recall that the optic radiations traveling deep in the parietal lobe carry information from the contralateral inferior quadrants.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

Vascular Supply to Forebrain: Medial temporal lobe, diencephalon, midbrain, occipital lobe medial and inferior surfaces, medial parietal lobe, splenium of corpus callosum, inferior and medial temporal lobe with hippocampal formation

A

Posterior Cerebral Artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

Penetrating Branches of PCA Key Functional Areas

A

-DIENCEPHALON including thalamus, subthalamic nucleus, and hypothalamus
-MIDBRAIN including cerebral peduncle, third nerve and nucleus, superior cerebellar
peduncle, reticular formation
-Note: The upper parts of the Basilar artery also help supply the midbrain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

Cortical Branches of PCA Key Functional Areas

A

PARIETAL AND OCCIPITAL LOBE (Posterior branches)
-Optic radiations and striate cortex (the primary visual cortex may be entirely
supplied by PCA, or the tip of the occipital lobe where the fovea is mapped may be
located in the border zone shared by PCA and MCA)
-Splenium of the corpus callosum (these crossing fibers participate in the transfer of
visual information to the language-dominant hemisphere)

MEDIAL TEMPORAL LOBE (Anterior branches)
-Posterior hippocampal formation and the fornix (these structures are critical for laying down new declarative memories)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

Surface view of Brain Vascular Territories: Midbrain and portions of ventral temporal and occipital lobe

A

Posterior Cerebral Artery (PCA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

Surface view of Brain Vascular Territories: Midline of Pons

A

Basilar artery (paramedian branches)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

Surface view of Brain Vascular Territories: Lateral Pons

A

Basilar artery (circumferential branches = lateral pontine branches)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
54
Q

Surface view of Brain Vascular Territories: Exposed portion of superior cerebellum

A

Superior Cerebellar Artery (SCA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
55
Q

Surface view of Brain Vascular Territories: Exposed flocculus and medial portions of cerebellum

A

Anterior inferior cerebellar artery (AICA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
56
Q

Surface view of Brain Vascular Territories: Exposed portions of inferior cerebellum (biventer lobule), tonsils, olives on medulla

A

Posterior inferior cerebellar artery (PICA)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
57
Q

Surface view of Brain Vascular Territories: lateral portions of pyramids and medulla (excluding olives)

A

Vertebral artery (lateral branches)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
58
Q

Surface view of Brain Vascular Territories: medial portions of pyramids and medulla

A

Vertebral artery (paramedian branches) and anterior spinal artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
59
Q

Coronal view of Cerebral Arterial Territories: Thalamus

A

PCA deep branches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
60
Q

Coronal view of Cerebral Arterial Territories: Hippocampal formation, 1/2 of GPi, portion of internal capsule

A

Anterior choroidal artery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
61
Q

Coronal view of Cerebral Arterial Territories: temporal lobe

A

PCA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
62
Q

Coronal view of Cerebral Arterial Territories: GPe, 1/2 of GPi, Putamen, portion of internal capsule

A

MCA deep branches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
63
Q

Coronal view of Cerebral Arterial Territories: Insular gyrus, superior temporal lobe

A

MCA inferior division

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
64
Q

Coronal view of Cerebral Arterial Territories: parietal lolbe superior to insular gyrus

A

MCA superior division

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
65
Q

Coronal view of Cerebral Arterial Territories: Cingulum and Cingulate gyrus, body of corpus callosum

A

ACA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
66
Q

Horizontal/Axial view of Cerebral Arterial Territories : Cingulum and Cingulate Gyrus, Genu of Corpus Callosum

A

ACA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
67
Q

Horizontal/Axial view of Cerebral Arterial Territories : Caudate Head, anterior limb of internal capsule

A

ACA deep branches

68
Q

Horizontal/Axial view of Cerebral Arterial Territories : Putamen, Globus Pallidus, Insula

A

MCA deep branches

69
Q

Horizontal/Axial view of Cerebral Arterial Territories : Posterior limb of internal capsule

A

Anterior choroidal artery

70
Q

Horizontal/Axial view of Cerebral Arterial Territories : Thalamus

A

PCA deep branches

71
Q

Horizontal/Axial view of Cerebral Arterial Territories : Splenium of corpus callosium, midline occipital regions

A

PCA

72
Q

Horizontal/Axial view of Cerebral Arterial Territories : lateral parietotemporaloccipital regions

A

MCA inferior division

73
Q

Horizontal/Axial view of Cerebral Arterial Territories : lateral fontoparietal regions

A

MCA superior division

74
Q

Blood vessels supplying the BG and thalamus: Head of caudate, Anterior putamen

A

Penetrating branches of ACA (e.g., recurrent artery of Heubner)

75
Q

Blood vessels supplying the BG and thalamus: Caudate nucleus body of putamen

A

Lenticulostriate arteries derived from MCA which is derived from internal carotid artery

76
Q

Blood vessels supplying the BG and thalamus: Posterior putamen, Globus pallidus, tail of caudate

A

Anterior choroidal artery derived from ACA which is derived from internal carotid artery

77
Q

Blood vessels supplying the BG and thalamus: Thalamus

A

Posterior choroidal artery, Thalamogeniculate arteries and Thalamoperforator arterys derived from PCA which is derived from basilar artery

78
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of L MCA superior division

A

Deficits:

  • Right face and arm weakness of the UMN type
  • Nonfluent or brocas aphasia
  • In some cases there may also be some R face and arm cortical-type sensory loss
79
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of L MCA inferior division

A

Deficits

  • Fluent or Wernickes aphasia
  • R visual field deficit
  • There may also be some right face and arm cortical-type sensory loss.
  • Motor findings are usually absent and patients may initially seem confused or crazy but otherwise intact, unless carefully examined.
  • Some mild right-sided weakness may be present, especially at the onset of symptoms
80
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of L MCA deep territory

A

Deficits:

  • Right pure motor hemiparesis of the UMN type.
  • Larger infarcts may produce “cortical” deficits, such as aphasia as well.
81
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of L MCA stem

A

Deficits:

  • Combination of MCA syndromes with R hemiplegia, R hemianesthesia, R homonymous hemianopia and global aphasia.
  • There is often left gaze preference especially at the onset, caused by damage to L hemisphere cortical areas important for driving eyes to the right.
82
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of R MCA superior division

A

Deficits:

  • Left face and arm weakness of the UMN type.
  • Left hemineglect is present to a variable extent.
  • In some cases, there may also be some left face and arm cortical-type sensory loss.
83
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of R MCA inferior division

A
  • Profound left hemineglect.
  • Left visual field and somatosensory deficts are often present; however these may be difficult to test convincingly because of the neglect.
  • Motor neglect with decreased voluntary or spontaneous initiation of movements on the L side can also occur.
  • However, even patients with L motor neglect usually have normal strength on the L side, as evidenced by occassional spontaneous movements or purposeful withdrawal from pain. Some mild, left-sided weakness may be present.
  • There is often a right gaze preference, especially at onset.
84
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of R MCA deep territory

A

Deficits:

  • L pure motor hemiparesis of UMN type.
  • Larger infarcts may produce “cortical” deficits such as L hemineglect as well.
85
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of R MCA stem

A

Deficits:

  • Combination of R MCA syndromes with left hemiplegia, left hemianesthesia, left homonomymous hemianopia and profound left hemineglect.
  • There is usually a right gaze preference, especially at onset, caused by damage to R hemisphere cortical areas important for driving the eyes to the left.
86
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of L ACA

A

Deficits:

  • R leg weakness of UMN type and R leg cortical-type sensory loss.
  • Grasp reflex
  • Frontal lobe behavioral abnormalities
  • Transcortical aphasia can also be seen.
  • Larger infarcts may cause R hemiplegia.
87
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of R ACA

A

Deficits:

  • L leg weakness of UMN type and L leg cortical-type sensory loss.
  • Grasp reflex
  • Frontal lobe behavioral abnormalities
  • L hemineglect can also be seen.
  • Larger infarcts may cause L hemiplegia
88
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of L PCA

A

Deficits:

  • Right homonymous hemianopia.
  • Extension to spenium of the corpus callosum can cause alexia without agraphia.
  • Larger infarcts, including the thalamus and interanl capsule, may cause aphasia, right hemisensory loss, and right hemiparesis
89
Q

Major Clinical Syndromes MCA/ACA/PCA Territories:

Infarct of R PCA

A

Deficits:

  • Left homonymous hemianopia
  • Larger infarcts including the thalamus and internal capsule may cause left hemisensory loss and left hemiparesis.
90
Q

Common Lacunar Syndromes:

Pure motor hemiparesis or dysarthria hemiparesis

Clinical Features

A

Unilateral face, arm, and leg UMN type weakness, with dysarthria

91
Q

Common Lacunar Syndromes:

Pure motor hemiparesis or dysarthria hemiparesis

Possible Locations for Infarct

A
  • Posterior limb of internal capsule (common)
  • Ventral pons (common)
  • Corona radiata
  • Cerebral peduncle
92
Q

Common Lacunar Syndromes:

Pure motor hemiparesis or dysarthria hemiparesis

Possible Vessels Involved

A
  • Lenticulostriate arteries (common), anterior choiridal artery or perforating brances of PCA for Posterior limb of IC infarct
  • Ventral penetrating branches of basilar artery for Ventral pons infarct
  • Small MCA branches for corona radiata infarct
  • Small proximal PCA branches for cerebral peduncle infarct
93
Q

Common Lacunar Syndromes:

Ataxic Hemiparesis

Clinical Features

A

Same as pure motor hemiparesis (i.e., unilateral face, arm and leg weakness of UMN type) but with ataxia on same side as weakness.

94
Q

Common Lacunar Syndromes:

Ataxic Hemiparesis

Possible locations for infarct

A
  • Posterior limb of internal capsule (common)
  • Ventral pons (common)
  • Corona radiata
  • Cerebral peduncle
95
Q

Common Lacunar Syndromes:

Ataxic Hemiparesis

Possible vessels involved

A
  • Lenticulostriate arteries (common), anterior choiridal artery or perforating brances of PCA for Posterior limb of IC infarct
  • Ventral penetrating branches of basilar artery for Ventral pons infarct
  • Small MCA branches for corona radiata infarct
  • Small proximal PCA branches for cerebral peduncle infarct
96
Q

Common Lacunar Syndromes:

Pure sensory stroke (thalamic lacune)

Clinical Features

A

Sensory loss to all primary modalities in the contralateral face and body.

97
Q

Common Lacunar Syndromes:

Pure sensory stroke (thalamic lacune)

Possible locations for infarct

A

Ventral posterior lateral nucleus of thalamus (VPL)

98
Q

Common Lacunar Syndromes:

Pure sensory stroke (thalamic lacune)

Possible vessels involved

A

Thalmoperforator branches of the PCA

99
Q

Common Lacunar Syndromes:

Sensorimotor stroke (thalamocapsular lacune)

Clinical Features

A

Combination of thalamic lacune (i.e., sensory loss to all primary modalities in the contralateral face and body) and pure motor hemiparesis (i.e, unilateral face, arm, and leg UMN type weakness)

100
Q

Common Lacunar Syndromes:

Sensorimotor stroke (thalamocapsular lacune)

Possible locations for infarct

A
  • Posterior limb of internal capsule

- Either thalamic VPL or thalamic somatosensory radiation

101
Q

Common Lacunar Syndromes:

Sensorimotor stroke (thalamocapsular lacune)

Possible vessels involved

A

Thalmoperforater branches of the PCA or lenticulostriate arteries

102
Q

Common Lacunar Syndromes:

Basal ganglia lacune

Clinical Features

A

Usually asymptomatic, but may cause hemiballismus (i.e., flinging/ballistic/chorea like movement of proximal arm or leg)

103
Q

Common Lacunar Syndromes:

Basal ganglia lacune

Possible locations for infarct

A
  • Caudate
  • Putamen
  • Globus pallidus
  • STN
104
Q

Common Lacunar Syndromes:

Basal ganglia lacune

Possible vessels involved

A
  • Lenticulostriate

- Anterior choroidal or Heubners arteries

105
Q

Watershed Areas

ACA-MCA Watershed

A

Coronal View:
-Goes from corona radiata (lateral to cingulum) to top gyrus border of ACA/MCA regions through the minimal first pronounced frontal sulcus visible.

Horizontal View:
-Goes from edge of anterior limb of internal capsule to top gyrus border of ACA/MCA regions through the minimal first pronounced frontal sulcus visible.

106
Q

Watershed Areas

MCA-PCA Watershed

A

Coronal View:
-Goes from edge of putamen to bottom gyrus border of MCA/PCA regions and covering the second pronounced gyrus inferiorly

Horizontal View:
-Goes from edge of atrium of lateral ventrical to bottom gyrus border of MCA/PCA regions and covering the second pronounced gyrus inferiorly

107
Q

Watershed Areas

Define + Causes

A
  • Watershed areas refers to arterial end-zones.
  • They are areas between major arterial supples (ACA/MCA, MCA/PCA) or at the end of small arteries (lenticulostriates)
  • Watershed damage occurs after drop in blood pressure secondary to stroke, heart attack or massive bleeding in the body
108
Q

Anterior Spinal Cord Syndrome

A
  • Most often caused by embolism due to complications of surgery (angiography) or trauma
  • Damage to STT causes lose of pain and temperature sensation BELOW the level of the lesion.
  • Damage to anterior horn cells produces LMN weakness AT the level of the lesion.
  • Larger lesions can includ CST and cause UMN symptoms below the lesion.
  • Posterior cord rarely affected by vascular pathology due to 2 posterior arteries and their connections to eachother
109
Q

NTL Lab Intro:

Left Hemisphere Lesions

A

Language deficit
Graphesthesia (inability to ID something drawn to your hand)
Eyes deviate left
R motor deficits

110
Q

NTL Lab Intro:

Right Hemisphere Lesions

A

L hemispatial neglect
Loss of prosody
Eyes deviate right
Left motor deficits

111
Q

NTL Lab Intro:

Internal capsule

A

Face, arm and leg involvement on the same side could indicate lesion of the internal capsule

112
Q

NTL Lab Intro:

Brainstem lesions

A

Sensory and motor signs in the body can be crossed with CN deficits

Medial pontine syndrome, results from occulsion of paramedian brances of basilar artery

113
Q

NTL Lab Intro:

Cerebellar Signs

A

Ataxia, nystagmus or dysdiadochokinesia are associated with cerebellar or cerebellar peduncle lesions.

Cerebellar signs are found on the SAME side of the body as the lesion.

114
Q

NTL Lab Intro:

Bitemporal Hemianopsia

A

Optic chaism affected

115
Q

NTL Lab Intro:

Homonymous Hemianopsia

A

Will localize it to either optic tract, LGN, or occipital lobe

116
Q

NTL Lab Intro:

Convergence

A

If CN3 is damaged they WILL NOT BE able to converge and look at the nose.

If CN3 is intact and they CAN CONVERGE, likely damage between CN3 and 6 via MLF.

117
Q

NTL Lab Intro:

Horizontal gaze deficits

A

Tells you where the lesion is, they will LOOK without deficits to the side of the lesion.

Appropriate Right Gaze = R MLF deficit.

“He can look to the right, so R MLF deficit”

or

IPSILATERAL MLF to the eye that cannot adduct past midline.

“Issues with adduction of R eye when looking left, so R MLF deficit”

118
Q

NTL Lab Intro:

Spinal Cord Lesions - Motor

A

Flaccid paralysis immediately after lesion, followed by spastic paralysis. Symptoms are on the SAME SIDE as lesion.

119
Q

NTL Lab Intro:

Spinal Cord Lesions - Sensory

A

Loss of pain and temperature on OPPOSITE side of body.
(because fibers cross immediately in ventral white commissure)

Loss of fine touch and proprioception on SAME SIDE of body.
(because fibers dont cross until you get up to sensory deccussation)

Classic presentation:
Brown Sequard Syndrome: IPSILATERAL weakness, IPSI LOSS of proprioception/vibration and CONTRA loss of pain temperature secondary to HEMICORD lesion

120
Q

NTL Lab Intro:

Spinal Cord Lesions - General

A

Typically no facial involvement. Think about the dermatomes.

121
Q

NTL Lab Intro:

Cranial Nerve Lesions

A

Loss of the entire nerve, including motor and sensory distribution (and associated reflexes!)

Think about unique functions of each nerve

May include loss of parasympathetic functions CN 3, 7, 9, 10

Example: Lack of pupillary response to light or lack of saliva production

122
Q

NTL Lab Intro:

Peripheral Nerve Lesion

A

Loss of the entire nerve, including motor and sensory distribution (and associated reflexes!)

LMN symptoms

Can see similar symptoms with central lesions, but central lesions are accompanied by other symptoms as well

123
Q

NTL Lab Intro:

Hx for differential diagnosis

A

Sudden onset suggests a vascular problem like hemorrhage or stroke

Progressive onset suggests a tumor or other progressive disease (e.g., MS)

124
Q

NTL Lab Intro:

Nystagmus

A

Cerebellum OR vestibular nuclei

125
Q

NTL Lab Intro:

Nausea/vomiting

A

Medulla OR vestibular nuclei OR increased ICP

126
Q

NTL Lab Intro:

Difficulty speaking

A

Cortical aphasia OR facial weakness OR tongue weakness

127
Q

NTL Lab Intro:

Anterior Spinal Artery Infarct

A

Will affect anterior 2/3 of the spinal cord (symptoms will include weakness)

128
Q

NTL Lab Intro:

Posterior Spinal Artery Infarct

A

If you have an infarct of the posterior spinal artery, it will involve the dorsal columns (symptoms tend to not include weakness but will have sensory loss of vibration and proprioception)

129
Q

NTL Lab Intro:

Vascular distribution in brainstem

A

In general, most brainstem syndromes are seperetaed into ventromedial and dorsal-lateral brainstem

130
Q

NTL Lab Intro:

Vascular distribution in brainstem (ANTEROMEDIAL)

A

Anteromedial areas suppled by anteromedial (paramedian) branches of basilar bifuncation and P1 segment

131
Q

NTL Lab Intro:

Vascular distribution in brainstem (ANTEROLATERAL)

A

Anterolateral areas supplied by anterolateral (short circumferential) branches of the quadrigeminal and medial posterior choroidal arteries.

132
Q

NTL Lab Intro:

Vascular distribution in brainstem (LATERAL)

A

Lateral areas (which are sort of square shaped and off midline; see images) are supplied by lateral branches of quadrigeminal (level of inferior colliculus) quadigeminal and posterior medial choroidal arteries (level of superior colliculus)

133
Q

NTL Lab Intro:

Vascular distribution in brainstem (MOST DORSAL)

A

Dorsal regions like superior colliculus/opposite of cerebral peduncles are supplied by quadrigeminal and superior cerebellar arteries (level of inferior colliculus), quadrigeminal and posterior medial choroidal arteries (level of superior colliculus)

134
Q

NTL Lab Intro:

Vascular distribution in brainstem (FAR LATERAL @ LEVEL 3 on)

A

Thalamogeniculate artery

135
Q

NTL Lab Intro:

Complete R facial droop

A

CN 7

136
Q

NTL Lab Intro:

Vomiting/Dizziness

A

CN 8, vestibular nucleus, ICP

137
Q

NTL Lab Intro:

Diminished taste sensation

A

CN 7, 9, X, NTS

138
Q

NTL Lab Intro:

Diminished pain and temperature one side of body

A

Contralateral STT/ALS (as its already crossed)

Contralateral spinal cord lesion

139
Q

NTL Lab Intro:

Decreased pain and temperature to one side of face

A

IPSILATERAL spinal nucleus of V, Chief sensory or VTTT

140
Q

NTL Lab Intro:

Weber syndrome:

A

Mesencephalon
Vascular distribution is P1 branch

Weber syndrome:
-Corticospinal fibers in cerebral peduncle result in contralateral hemiparesis with ipsilateral CN 3 palsy

141
Q

NTL Lab Intro:

Claude Syndrome

A

Mesencephalon
Vascular distribution is P1 branch

Claude syndrome:
-Red nucleus and cerebellothalamic fiber insult resulting in contralateral ataxia and tremor with ipsilateral CN 3 palsy

142
Q

NTL Lab Intro:

Benedikt syndrome

A

Combination of both Weber and Claude

143
Q

NTL Lab Intro:

Medial pontine syndrome

A

Pons
Vascular distribution paramedian brances of basilar

Medial Pontine Syndrome:

  • Corticospinal fiber damage resulting in contralateral hemiparesis
  • ML damage resulting in contralateral loss of proprioception/vibration (left side)
  • Abducens nucleus or nerve fiber damage resulting in ipsilateral loss of eye abduction (lateral rectus)
  • PPRF damage results in paralysis of conjugate gaze toward the side of the lesion.
144
Q

NTL Lab Intro:

Lateral pontine syndrome

A

Pons
Vascular distribution long circumferential branches of basilar

Lateral pontine syndrome (Millard-Gubler syndrome)

  • Middle/superior cerebellar peduncle damage causing ataxia and falling towards side of lesion.
  • Vestibular and cochlear nerves/nuclei damage resulting in ipsilateral deafness, vertigo, tinnitus and vomiting.
  • Facial motor nucleus damage resulting in ipsilateral facila paralysis
  • Trigeminal motor nucleus damage resulting in ipsilateral paralysis of masticatory muscles
  • Sympathetic fiber damage resulting in ipsilateral horner’s syndrome
  • STT and nucleus resulting in ipsilateral loss of facial pain/temp and contralateral loss of body pain/temp
  • PPRF damage causing paralysis of conjugate horizontal gaze
145
Q

NTL Lab Intro:

Medial medullary syndrome (Dejerine syndrome)

A

Medulla
Vascular distribution branches from anterior spinal artery

Medial medullary syndrome (Dejerine syndrome)

  • Corticospinal fibers in pyramid damage resulting in contralateral hemiparesis
  • ML damage resulting in contralateral loss of touch/position/vibration sense
  • Hypoglossal nerve nucleus resulting in deviation of tongue to IPSILATERAL side
146
Q

NTL Lab Intro:

Lateral medullary syndrome (Wallenberg Syndrome)

A

Medulla
Vascular distribution branches from anterior spinal artery

Lateral medullary syndrome (Wallenberg Syndrome)

  • STT and nucleus resulting in ipsilateral loss of facial pain/temp and contralateral loss of body pain/temp
  • NA damage causing dysphagia and decreased gag
  • Sympathetic fiber damage resulting in ipsilateral horner’s syndrome
  • Damage to vestibular nuclei causing nystagmus, diplopia and tendency to fall to ipsilateral side
  • ICP damage causing ipsilateral ataxia
147
Q

NTL Lab Intro:

Cortical Stroke Syndromes
MCA

A

MCA

Contralateral face/arm weakness, sensory loss, eye movement abnromalities and/or aphasia (L side)

148
Q

NTL Lab Intro:

Cortical Stroke Syndromes
ACA

A

ACA

Contralateral leg weakness, behavioral abnormalities.

Behavioral changes due to involvement of the limbic system, caudate and some orbitofrontal cortrex.

149
Q

NTL Lab Intro:

Cortical Stroke Syndromes
PCA

A

PCA

Contralateral homonymous hemianopia with macular sparing, memory problems.

Memory deficits due to involvement of inferior temporal lobe, parahippocampal gyrus and hippocampus

150
Q

Eye Movement Lab Intro:

Foveation

A

The system evolved to maintain foveation.

Fovea is the area of the retina with the highest visual acuity.

151
Q

Eye Movement Lab Intro:

3 primary types of movements

A

Saccades

Smooth pursuit

Vergence (con- or di-

Can be supranuclear or nuclear; under reflexive or voluntary control; seperate systems for vertical + horizontal eye movements

152
Q

Eye Movement Lab Intro:

Saccades

A

Quick, darting CONJUGATE movements which direct the eyes to a new target.

Conjugate meaning same time, direction, perfectly nysnc.

FEF control voluntary saccades

Superior colliculi control reflexive saccades in tandem with TST.

153
Q

Eye Movement Lab Intro:

Smooth Pursuit

A

A slower conjugate movement which allows for tracking of a moving object or of a stationary object while we are moving

154
Q

Eye Movement Lab Intro:

Vergence

A

Convergence is DISconjugate movement of both eyes toward midline to allow for focusing on a near object by adjusting the angle between the eyes

155
Q

Horizontal Gaze under Supranuclear Control

A

FEF for saccades is CONTRA to direction of gaze.

Look horizontally to RIGHT.
LEFT FEF has to fire to activate RIGHT PONS/PPRF/6/MLF/3

TOPJ for smooth pursuit is is IPSILATERAL to direction of gaze.

Look horizontally to RIGHT.
RIGHT TOPJ fires to activate RIGHT PONS/PPRF/6/MLF/3.

156
Q

Vestibulo-ocular reflex (VOR)

A

Reflexive movements which are under nuclear control alone (specifically, under control of the vestibular nuclei in the brainstem. These constitue what is called the VOR.

157
Q

Supranuclear = Gaze Palsy

A

FEF lesion

PPRF lesion

158
Q

Nuclear = Gaze palsy

A

Nuclear lesion (only 6 nucleus is relevant here

159
Q

Intranuclear = Mixture of gaze and nerve palsy

A 
MLF Lesion (L5) 
MLF Lesion + nucleur lesion (L6)
160
Q

Infranuclear

A

Nerve Palsy

CN 3, 4, 6 palsy

161
Q

6th nucleus lesion

A

Gaze palsy to ipsilateral side that CANNOT be overcome by VOR

162
Q

PPRF lesion

A

Gaze palsy to the ipsilateral side that CAN be overcome by VOR, acutely eyes may be deviated contralaterally

163
Q

FEF lesion

A

palsy of saccades to contralateral side. Acutely, eyes may be deviated toward the side of the lesion

164
Q

INO

A

Internucleur opthalmoplegia:

Lesion of the MLF. Eye ipsilateral to the lesion cannot adduct. Contralateral eye can normally abduct, but nystagmus present.

165
Q

1 1/2 syndrome

A

Combination of ipsilateral gaze palsy and INO

166
Q

PPRF lesions at the level of abducens…

A 
PPRF lesions at the level of abducens
are associated with ipsilateral gaze palsy
and loss of reflex vestibular (and tonic
neck) movements
This presumes that there is a critical
synapse within the caudal PPRF for the
vestibulo-ocular pathways or that the
functional integrity of the PPRF at that
level is necessary for vestibulo-ocular eye
movements

Functional Human Neuroanatomy (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions