Nervous System Flashcards
3 Major Levels of CNS Function
- Spinal Cord Level (walking, withdrawal, reflex, body support, etc.)
- Lower brain/subcortical level (subconscious activities, equilibrium, feeding reflexes, emotion)
- Higher brain/cortical level (memory storehouse, thought process)
Neurotransmitters
chemical substances that function as synaptic transmitters, main communicators between neurons. Release though exocytosis into the cleft, and will then bind to receptor proteins.
What is calcium responsible for?
Opening the chemically-gated channels
Process: Step 1
Action potential reaches axon terminal of presynaptic neuron
Process: Step 2
Calcium enters synaptic knob (presynaptic axon terminal)
Process: Step 3
Neurotransmitter is released by exocytosis into synaptic cleft
Process: Step 4
Neurotransmitter binds to receptors that are an integral part of chemically gated channels on subsynaptic membrane of postsynaptic neuron
Process: Step 5
Binding of neurotransmitters to receptor opens that specific channel
Are chemically and voltage-gated channels involved in this process?
Yes.
Neurotransmitters: small, rapidly acting transmitter examples:
Acetylcholine, norepinephrine, dopamine, serotonin, GABA, glycine, glutamate, nitric oxide
Neurotransmitters: neuropeptide, slowly acting transmitter examples:
Hypothalamic releasing hormones (TRH, LHRH) Pituitary peptides (ACTH, prolactin, vasopressin, etc)
Excitatory neurons:
Na influx, spread of action potential
Inhibited neurons:
Cl influx, K efflux, ways of calming down the responses of the nervous system
Are there different neurotransmitters for excitatory and inhibitory responses?
Yes!
Properties of Neuronal Activity
Presynaptic inhibition (GABA)
Spatial summation
Temporal summation
Facilitation of neurons
Spatial summation:
a sum of a number of APs in a certain space
Temporal summation:
a sum of a number of APs in a certain number of time
Facilitation of neurons:
neurons close to each other will help each other out/facilitate each other.
Fatigue
fatigue is a protection mechanism for ourselves to stop when we need to. (ex: low calcium, availability of neurotransmitters)
Acidosis
depresses neuronal activity, pH change from 7.4 to 7.0… coma
Alkalosis
increases neuronal excitability, pH change from 7.4 to 8.0… seizures
Hypoxia
interruption of brain blood flow for 3 to 7 seconds… unconsciousness. Low levels of oxygen in the blood!
Receptor excitation
if receptor potential is large enough, then an action potential will be generated
Receptor potentials and action potentials
the greater the receptor potential is over the threshold, the higher the frequency of the action potentials
What causes the receptor potential to move over the threshold?
the actual stimulus
Adaptation of Receptors
when a continuous stimulus is applied, receptors respond rapidly at first, but response declines until all receptors stop firing. This varies depending on the receptor
Slow Adapting (Tonic) Receptors
Transmit impulses to the brain for long periods of time, keep brain apprised of the status of the body with respect to its surroundings. Receptors include muscle spindles, golgi tendon apparatus, Ruffini’s endings, Merkel discs, chemo and baro-receptors
Rapidly adapting (phasic) receptors
respond only when a change is taking place, rate, strength of the response is related to the rate and intensity of stimulus and are important for balance and movement and predicting the future position or condition of the body. Include: pacinian corpuscle, semicircular canals
Neuronal Pools: discharge zone
main site of excitability
Neuronal Pools: facilitated zone
helps to assist the discharge zone if necessary, can facilitate the process
Pathways for transmission of sensory information
enters the spinal cord through the dorsal roots of the spinal nerves
2 pathways for sensory info:
- Dorsal column system
2. Anterolateral system