Neuraminidase Inhibitors

Question 1

Examples:

Answer 1

1. Oseltamivir - oral
2. Peramivir - IV
3. Zanamivir - inhaled

Question 2

MOA:

Answer 2

1. Inhibits viral neuraminidase enzyme
2. Trapping virus within infected host cell
3. Preventing spread to neighbouring cells

Question 3

Spectrum:

Answer 3

1. Respiratory viruses - influenza

Question 4

Indications:

Answer 4

1. Preventing influenza - household contacts or nursing homes
2. NOT very effective in Rx of influenza especially post 48 hours infection

Question 5

S/E:

Answer 5

1. Oseltamivir - Nausea, Vomiting, Epigastric distress
2. Zanamivir - Bronchospasm

Question 6

Stewardship:

Answer 6

1. Unlikely to be effective after 48 hours
2. Still evidence of decreased mortality with Rx in hospitalised patients
3. Give empirically early in admission for greatest benefit
4. NOT to be used for routine or widespread chemoprophylaxis