Neuro Flashcards
Migraine Presentation
- unilateral
- throbbing
- +/- aura
- menstrual (2 days b/f and last day)
- photophobia
- N&V
- aggravated by movement
-brought on by hormones, stress, lack of sleep, alcohol,
smoking, weather changes
- 4 to 72 hours
PUNT (photophobia, unilateral, nausea, throbbing)
Migraine Tx
ACUTE - Excedrin (acetaminophen + ASA+ caffeine), NSAIDs, triptans (oral, nasal, IV, injection), DHE (dihydroergotamine)
**Do not use oral if associated w/ N&V
PPX - amitryptiline, propranolol, valproate, topiramate, verapamil
Cluster Headache Presentation
- unilateral
- orbital, supraorbital, temporal
- deep, excruciating pain (15 min - 3 hr)
- ipsilateral autonomic signs (lacrimation, d/c and facial flushing)
- more common in men
- Tend to pace/ cannot get comfortable
- Episodic (2-3 months then remission for mo to yrs) OR chronic (1-2 yrs w/o remission)
Cluster Headache Tx
1st line ACUTE -100% O2 at 6L and triptans
PPX - verapamil (first line), lithium, ergotamine, prednisone
Tension Headache Presentation
MOST COMMON
- band/ bilat w/ muscle tenderness
- no nausea, vomiting, aggravation w/ movement
- Associated w/ stress, depression, anxiety
Tension Headache Tx
Try ASA, acetaminophen and NSAIDs
Then combine w/ caffeine
Try to limit med use to 2-3 days / wk otherwise get med overuse headaches
If chronic … stress mgt, antidep, amitriptyline is first line (also venlafaxine, Ca blockers, beta blockers)
Secondary Causes of Headache
VOMIT
- V - vascular (hemorrhage, hematoma, temporal arteritis)
- O - other (malignant HTN, pseudo tumor cerebri, post LP, pheochromocytoma)
- M - meds (analgesic abuse, alcohol withdrawal, nitrates)
- I - infection (meningitis, encephalitis, sinusitis, cerebral abscess, zoster, fever)
- T - tumor
Contradictions to Migraine Meds
- Dihydroergotamine (DHE) - serotonin agonist; do not use if CAD, pregnancy, hx TIAs, PAD, sepsis
- Sumatriptan - more selective serotonin agonist; do not use if CAD, pregnancy, uncontrolled HTN, basilar artery migraine, hemiplegic migraine, if on MAOIs, SSRI or lithium
Approach to Coma
- 1- ABC’s
- 2- rapid neuro exam (asymmetry suggests mass lesion)
- 3- brainstem reflexes
- Pupil light reflex - if intact then brainstem okay; asymmetric may mean uncle herniation
- Eye movements - if turn head and eyes move to opposite side then brainstem okay
- Breathing on own? then brainstem okay
- 4- Labs - CBC, CMP, glucose, plasma Osm, blood gas
- 5- ECG
- 6- Toxicology analysis of blood and urine
- 7- CT / MRI of brain
- 8- LP if meningitis suspected
Glasgow Coma Scale
- Eye Opening
- 1- do not open
- 2- open to painful stim
- 3- open to voice
- 4- open spont
- Motor
- 1- no movement
- 2- decerebrate
- 3- decorticate
- 4- withdraws from pain
- 5- localizes pain stimulus
- 6- obeys commands
- Verbal
- 1- no sounds
- 2- incomprehensible sounds
- 3- inappropriate words
- 4- appropriate but confused
- 5- appropriate and oriented
Bilateral Fixed Dilated Pupils
severe anoxia
Unilateral Fixed Dilated Pupils
uncal herniation (CN III compressed)
Pinpoint Pupils
Narcotics
ICH
Locked In Syndrome
completely paralyzed except respiration, blinking and vertical eye movements
fully aware and feel pain
ventral pons damage
Reversible Causes of Dementia (8)
- Hypothyroid
- Neurosyphilis
- B12/folate/thiamine def
- Niacin def
- Meds
- Normal pressure hydrocephalus
- Depression
- Subdural hematoma