Neuroanatomy Reticular Formation & Cerebellum Flashcards

1
Q

What is the central core of the brainstem?

A

the reticular formation

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2
Q

The reticular formation extends into the cerebrum as what?

A

the hypothalamus

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3
Q

The reticular formation (which extends into the cerebrum as the hypothalamus) is important in the regulation of what 6 things?

A

1) posture
2) some motor behaviors
3) the internal environment
4) pain
5) sleep and wakefulness
6) emotional tone

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4
Q

The three major cell columns of the reticular formation are what?

A

1) median reticular formation (raphe nuclei)
2) paramedian reticular formation (magnocellular neurons)
3) lateral reticular formation (parvocellular neurons)

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5
Q

What is the main sensory input to the reticular formation?

A

parvocellular nuclei

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6
Q

Point out the reticular formation

A
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7
Q

Does the limbic system input to the reticular formation? If so, what areas contribute to its input?

A

yes, and the input comes from the hippocampus, the amygdala, and prefrontal cortex

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8
Q

Are the outward projections from the reticular formation afferent or efferent?

A

efferent, to the spinal cord, limbic system, and all of the cortex

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9
Q

What part of the brain is serotonin associated with?

A

The raphe nuclei which projects to all regions of the cortex. Serotonin minimizes distractions, is involved with day-night cycle, suppresses pain, elevates mood, and is a common element in antidepressant medications (SSRIs)

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10
Q

What part of the brain is dopamine associated with?

A

Substantia nigra which projects to basal ganglia and is important in motor control

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11
Q

What is an easy way to remember the function of dopamine?

A

DOpamine “DOes” things

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12
Q

Identify the ventral tegmentum and the substantia nigra

A
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13
Q

Dopamine is associated with mesolimbic fibers and mesocortical fibers. To where do each project and what is associated with each?

A

mesolimbic fibers project to the limbic system and nucleus accumbens (signals emotional reward, is involved in drug dependency, and schizophrenia)

mesocortical fibers project to the entire cerebral cortex; especially the prefrontal lobe (organized thinking and planning [schizophrenia] )

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14
Q

The locus cerules, associated with norepinephrine, projects where and does what?

A

projects to the entire cerebral cortex and alerts cortex to novel stimuli (potential threats)

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15
Q

The ventrolateal medulla, associated with norepinephrine, projects where and does what?

A

projects to the spinal cord and inhibits pain

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16
Q

What two places in the brain is acetylcholine associated with

A

dorsolateral pontine tegmentum (important in ascending reticular activating system and control of sleep and wakefulness)

basal forebrain (basal nucleus) (supports cognition which is lost in alzheimers)

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17
Q

Where is the ascending reticular activating system?

A

dorsolateral pontine tegmentum (ACh, NE, and 5HT)

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18
Q

To what two organs do the fibers of the ascending reticular activating system go?

A

1) thalamus (to alert the cerebral cortex and maintain wakefulness)
2) preoptic portion of the hypothalamus (to block sleep)

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19
Q

Inhibition of activity of the preoptic area of the hypothalamus produces what result?

A

wakefulness, associated with the ASCENDING reticular activating system

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20
Q

Activity in what organ helps MAINTAIN the state of wakefulness (in contrast to the preoptic area of the hypothalamus PRODUCING wakefulness)

A

the lateral hypothalamus MAINTAINS wakefulness

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21
Q

Once every 24 hours, the _____ area of the _____ becomes dominant and switches off the dorsolateral pontine tegmentum to produce sleep

A

preoptic, hypothalamus

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22
Q

Precalculated rhythmic motor patters are associated with which three activities?

A

1) locomotion (gigantocellular nuclei)
2) eye movement control (paramedian pontine reticular formation)
3) chewing (supratrigeminal nucleus)

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23
Q

The supratrigeminal nucleus alternates activation between what two things?

A

jaw opening and jaw closing muscles

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24
Q

What are two theories that desribe bruxism activities?

A

1) malocclusion
2) sleep disorders

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25
Q

Where in the brain is the periaqueductal gray found?

A

midbrain (immediately surrounding the cerebral aqueduct)

26
Q

What two systems input to the periaqueductal gray?

A

1) limbic system
2) ascending sensory systems

27
Q

Output of the periaqueductal gray goes to where?

A

the lower brainstem reticular formation including the nucleus raphe magnus, trigeminal spinal nucleus, and spinal cord

28
Q

Activity in which area of the brain inhibits incoming pain signals?

A

periaqueductal gray

29
Q

what part of the brain specifically regulates heart & respiration rates?

A

periaqueductal gray

30
Q

Does the periaqueductal gray initiate panic behavior?

A

yes

31
Q

What is the major function of the cerebellum?

A

motor coordination

32
Q

What are the three divisions of the cerebellum?

A

1) vestibulocerebellum
2) spinocerebellum
3) neocerebellum

33
Q

What are the three cerebellar nuclei?

A

1) fastigial nucleus
2) interposed nucleus
3) dentate nucleus

34
Q

What are the three cell types in the cerebellum?

A

1) granular cell
2) purkinje cell
3) cerebellar nuclear cell

35
Q

In the cerebellum, zones and microzones include groups of what kind of cells?

A

purkinje cells

36
Q

In the cerebellum, what kind of fibers run parallel to folia?

A

parallel fibers

37
Q

Purkinje cell dendrites lie (parallel or perpedicular) to parallel fibers?

A

perpendicular

38
Q

Are zones and microzones in the cerebellum (with their groups of purkinje cells) served by input from a single area or multiple areas?

A

single area

39
Q

identify the three divisions of the cerebellum

A
40
Q

mossy fibers arise from _____ _____ & _____ sensory pathways

A

1) spinal cord
2) brainstem

41
Q

Granular cells are _____ and give rise to _____ fibers

A

excitatory

parallel

42
Q

Activation of granular cells happens via what?

A

via mossy fibers

43
Q

activation of granular cells produces what from purkinje cells?

A

simple spikes

44
Q

Purkinje cell axons are _____ and are the only fibers the leave the _____

A

inhibitory, cerebral cortex

45
Q

Climbing fibers arise from the _____ and provide excitatory input to the _____ and cause the ____ cell to produce complex spikes

A

inferior olive, purkinje dendrites, purkinje

46
Q

interneurons include _____, _____, &_____ and are also GABAergic (_____)

A

stellate, basket, golgi neurons

inhibitory

47
Q

Purkinje cells project to _____

A

cerebellar nuclei

48
Q

Cerebellar nuclei project to ____

A

the thalamus

49
Q

Thalamus projects to _____

A

motor cortex

50
Q

motor cortex projects to _____

A

basilar pons

51
Q

Basilar pons projects _____ to _____

A

mossy fibers to granular cells

52
Q

granular cells project to _____

A

purkinje cells

53
Q

The olivo-cerebellar circuit controls _____

A

timing

54
Q

Activation of climbing fibers to produce _____ complex spikes called a _____ signal

A

purkinje

teaching

55
Q

What are the three peduncles of the cerebellum and are they primary input and output

A

inferior - input

middle - input

superior - output

56
Q

The function of the vestibulocerebellum is what two things?

A

1) coordination of eye movements
2) balance

57
Q

What is the function of the spinocerebellum?

A

coordination of spinal cord generated movements and balance

58
Q

What are the two functions of the pontocerebellum?

A

1) coordination of upper extremity
2) coordination of speech

59
Q

What are 2 effects of a lesion of the vestibulocerebellum

A

1) back and fourth eye movements (nystagmus)
2) disturbances in balance while seated (truncal ataxia)

60
Q

What is the effect of a lesion of the spinocerebellum?

A

Stance and gait ataxia (“can you walk on this white line?”)

61
Q

Effect of a lesion in the neocerebellum?

A

involvement of arm and speech

  • rapid alternating movements
  • finger to nose
  • scanning or explosive speech
62
Q
A