Neurones and Drugs Flashcards
what are the two main cells of the brain?
glia and neurons
what are the parts to a neuron?
input; dendrites, integration; cell body(soma) and output; axon
three points about proteins in neural membranes?
some form ion channels which open and close by conformational change, generally specific for 1 ion and selectivity based on charge and size
what are the 3 major ions when considering neural activity?
Na, Cl and K
what is the equillibrium point for resting potential?
-50 to -70mV
desribe the permeability of the membrane at resting potential for ions?
high for K, low for Na and Cl
describe what happens to K when gradient is electical and concentration based and resting potential
resting = no movement
electrical = k moves in to cell
conc gradient = k moves out of cell
how does the impulse move down axon?
through the Na and K channels
what is salatory conduction?
basic neural process, myelin sheath and the action potential generated moves between gaps in nodes , impulse travels from one ranvier to another
what is a node?
gaps between them is where channels open
3 points about the end of an axon?
pre-synaptic terminal, axons branch and make many synapses, not all onto dendrites but most are
3 points about dendrites?
post-synaptic termical, many inputs to each neuron, most onto dendrites
what is the synaptic cleft?
gap between neurons
4 stages of pre-synaptic stage of chemical synapse?
axon terminals contain vesicles, vesicles contain neurotransmitter molecules, when ca enters the vesicles fuse with membrane and release neuro-transmitter into cleft, vesicles originate in the soma, recylced by cisternae in the terminal
what are the 3 stages of chemical synapse?
pre-synaptic synapse, release of molecule into cleft and activation of specific receptor
