Neurotransmitters (Mechanisms) Flashcards

1
Q

Acetylcholine (Muscarinic) - Excitatory

A

↑ IP3, DAG
↓ K conductance

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2
Q

Acetylcholine (Muscarinic) - Inhibitory

A

↑ K conductance
↓ cAMP

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3
Q

Acetylcholine (Nicotinic)

A

Excitatory
↑ Cation conductance

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4
Q

Dopamine (D1)

A

Inhibitory
↑ cAMP

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5
Q

Dopamine (D2) - Presynaptic

A

Inhibitory
↓ Ca conductance

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6
Q

Dopamine (D2) - Post-synaptic

A

Inhibitory
↑ cAMP
↓ K conductance

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7
Q

GABA-B - Presynaptic

A

Inhibitory
↓ Ca conductance

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8
Q

GABA-A

A

Inhibitory
↑ Cl conductance

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9
Q

GABA-B - Post-synaptic

A

Excitatory
↑ K conductance

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10
Q

Glutamate (NMDA)

A

Excitatory
↑ Cation (Ca) conductance

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11
Q

Glutamate (AMPA)

A

Excitatory
↑ Cation conductance

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12
Q

Glutamate (Kainate)

A

Excitatory
↑ Cation conductance

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13
Q

Glutamate (Metabotropic) - Presynaptic

A

Inhibitory
↓ Ca conductance

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14
Q

Glutamate (Metabotropic) - Post-synaptic

A

Excitatory
↑ IP3, DAG
↓ K conductance

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15
Q

Glycine (Taurine)

A

Inhibitory
↑ Cl conductance

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16
Q

Serotonin (5-HT1A)

A

Inhibitory
↑ K conductance
↓ cAMP

17
Q

Serotonin (5-HT2A)

A

Excitatory
↑ IP3, DAG
↓ K conductance

18
Q

Serotonin (5-HT3)

A

Excitatory
↑ Cation conductance

19
Q

Serotonin (5-HT4)

A

Excitatory
↓ K conductance

20
Q

Norepinephrine (α1)

A

Excitatory
↑ IP3, DAG
↓ K conductance

21
Q

Norepinephrine (α2)

A

Inhibitory
↑ K conductance
↓ cAMP

22
Q

Norepinephrine (α2) - Presynaptic

A

Inhibitory
↓ Ca conductance

23
Q

Norepinephrine (β1)

A

Excitatory
↑ K conductance
↓ cAMP

24
Q

Norepinephrine (β2)

A

Inhibitory
↑ Electrogenic pump
↑ cAMP

25
Q

Histamine (H1)

A

Excitatory
↑ IP3, DAG
↓ K conductance

26
Q

Histamine (H2)

A

Excitatory
↑ K conductance
↓ cAMP

27
Q

Histamine (H3)

A

Inhibitory
Autoreceptors

28
Q

Opioid Peptide (Mu) - Presynaptic

A

Inhibitory
↑ cAMP
↓ Ca conductance

29
Q

Opioid Peptide (Delta) - Post-synaptic

A

Inhibitory
↑ K conductance
↓ cAMP

30
Q

Opioid Peptide (Kappa) - Post-synaptic

A

Inhibitory
↑ K conductance
↓ cAMP

31
Q

Orexin (OX1)

A

Excitatory
Glutamate co-release

32
Q

Orexin (OX2)

A

Excitatory
Glutamate co-release

33
Q

Tachykinin (NK1)

A

Excitatory
↑ IP3, DAG
↓ K conductance

34
Q

Tachykinin (NK2)

A

Excitatory
↑ IP3, DAG
↓ K conductance

35
Q

Tachykinin (NK3)

A

Excitatory
↑ IP3, DAG
↓ K conductance

36
Q

Endocannabinoid (CB1) - Presynaptic

A

Inhibitory
↓ Ca conductance
↓ cAMP