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Pharm NMD > NMB > Flashcards

NMB Flashcards

1
Q

NMB produce histamine release (2)

A

Succy, Atracurium

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2
Q

Temp and pH sensitivity

A

Cisastracurium and Atracurium; due to Hoffman elimination

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3
Q

Causes allergic reaction pts sensitive to bromides

A

Atracurium and Pancuronium

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4
Q

Laudanosine toxicity (metabolite)

A

Atracurium and Cisatracurium

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5
Q

Not compatible with alkaline solution

A

Cisastracurium and Atracurium

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6
Q

Significantly increases HR and may be detrimental for pts with CAD and idiopathic hyperthorphic subarotic stenosis

A

Pancuronium

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7
Q

What sx present as laudanosine toxicity

A

CNS excitation, seizures, increased MAC?

Laudanosine crosses BBB, highly lipid soluble

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8
Q

Vagolytic effect

A

Pancuronium

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9
Q

Potentiates opioids

A

Vecuronium, produces bradicardia

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10
Q

Steroids

A

Rocuronium, Vecuronium, pancuronium

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11
Q

Drugs excreted by kidneys have longer or shorter duration

A

Longer

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12
Q

Drugs excreted by liver have longer or shorter duration

A

SHorter

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13
Q

Isoquinolines

A

Atracurium, Cisastracurium, and Tubocuranie

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14
Q

Produces 3OH metabolite

A

Vecuronium

3OH metabolite is 80% of potency which means that when it is metabolized it is still potent and gives effect

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15
Q

What factors decrease potency of NMB

A

Anticonvulsants; phenytoin and carbamazepine

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16
Q

Chemical incompatible with alkaline solutions

A

Atracurium and cisatracurium

Pharm NMD (1 decks)

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