NOACs

Question 1

Rivaroxiban

Answer 1

Xa inhibitor
reduced ICH
inc’d bleeding with with inhibitors of CYP3A4 - azoles, protease inhibitors, clarithromycin
DO NOT USE CrCl<30

Question 2

Apixiban

Answer 2

Xa inhibitor
BID (5 or 2.5)
2.5 dose for 2/3 of:
1) Age>60
2) Wt < 60kg
3) Cr >1.5

Best with renal patients (75% fecal excretion)

Question 3

Edoxiban

Answer 3

Xa inhibitor

Do not use with NORMAL Cr Cl >95

Question 4

Dabigitran

Answer 4

reversible thrombin (IIa) inhibitor
DO NOT USE CrCl<30

Question 5

NOACS and HIV

Answer 5

do not use for afib VTE ppx - interaction with protease inhibitors (levels of NOACs increase) - use warfarin

Question 6

Warfarin

Answer 6

Vit K antagonist (II, VII, IX, X)