Notes12

Question 1

lewis base

Answer 1

electron pair donor/nucleophile

Question 2

lewis acid

Answer 2

electron pair acceptor/electrophile

Question 3

high electron density centers=

Answer 3

lewis base

Question 4

basicity periodic trends

Answer 4

up and to the left. nucleophiles down and to the left

Question 5

basic vs nucleophilic behavior

Answer 5

• base only wants protons
• nucleophiles want positive charge electrophiles
• smaller size makes MUCH better nucleophiles

Question 6

substrate

Answer 6

usually refers to electrophile

Question 7

electrophilic centers

Answer 7

regions of low electron density. good electrophiles will have at least one resonance form without complete octet

Question 8

heteroatoms with positive charge

Answer 8

draw electron density.make neighboring C’s electrophilic or protons acidic

Question 9

how to tell delta+

Answer 9

draw out lewis structures

Question 10

equilibrium in acid/base

Answer 10

look at pairs of A/CB. which side is favored considering acidity of proton? which is more stable?

Question 11

a weak base=a

Answer 11

strong acid. doesnt want its protons too badly

Question 12

bronsted vs lewis base Ea

Answer 12

bronsted has a much lower Ea because hydrogens found on outside of molecule

Question 13

measuring basicity vs nucleophilicity

Answer 13

basicity - measure equilibrium (rxn rate almost instantaneous)
nucleophilicity - measure reaction rate

Question 14

good leaving groups are

Answer 14

WEAK bases