NSAIDS

Question 1

Nsaids are ______________ drugs?

Answer 1

weak acidic drugs

Question 2

What are NSAIDs mainly used for ?

Answer 2

to treat pain,fever and inflammation

Question 3

What are the pharmacological effects of NSAIDs?

Answer 3

reversible inhibition of cyclooxygenase(COX)

Question 4

What is COX ?

Answer 4

enzyme that catalyzes the first step in the synthesis of prostaglandins from arachionoid acid and other precursors

Question 5

COX activity is decreased primarly by ________?

Answer 5

competive inhibition

Question 6

What is the net effect of NSAID’s ?

Answer 6

decrease in the production of prostaglandins and other autoacids

Question 7

Only ___________ is NOT a reversible inhibition of cyclooxygenase?

Answer 7

Aspirin

Question 8

Prostaglandins are released from cells in response to?

Answer 8

chemical stimuli or physical trauma

Question 9

During inflammation ,immune cells release phospholipase A2, which turns phospholipids into?

Answer 9

arachonoid acid which is a substrate to COX

Question 10

Prostaglandins amplify ______?

Answer 10

Pain stimulus

Question 11

Prostaglandins sensitize?

Answer 11

sensory nerve endings to nocireceptive stimuli

Question 12

Prostaglandings promote tissue ________?

Answer 12

tissue inflammation by stimulating inflammatory cell chemotaxis,vasodilatation and increasing capillary permeability, leading to edema

Question 13

Nsaids that reffered to have “housekeeping” functions

Answer 13

COX -1

Question 14

NSAIDs’s that are termed as inducible and proinflammatory?

Answer 14

COX -2

Question 15

What is a type of irreversible cox inhibitors?

Answer 15

Aspirin

Question 16

What are the 2 subtypes of reversible COX inhibitors?

Answer 16

1.Non-selective cox inhibitors
2. Selecetive cox inhibitors

Question 17

What is a type of non-selective cox inhibitors?

Answer 17

ibuprofen,naxoproxen,sulidac,indomethacin

Question 18

What is a type of selective-cox inhibitors ?

Answer 18

celecoxib and glucocorticoids