obesity Flashcards
symptoms of leptin reistance
infertility
overweight:
-extreme hunger and eating
-lowered energy expenditure
what does leptin do?
gives signal to brain that ur fat levels are enought, ur not starving
can giving leptin to ppl without leptin def help with obesity?
no, EXCESS leptin deosnt help bc its just an anti starvation hormone
what condition can we use leptin for? how long does it take to act and whats the effect
hypothalamic ammenorhoea in women
representative pattern of LH pulsatile characteristics at baseline after 2 weeks of leptin therapy
where do we get orlistat from ?
an endogenous lipstatin produced by Streptomyces toxytricini.
what is the action of orlistat and effect?
Gastric and pancreatic lipase inhibitor
Reduces dietary fat absorption by around 30%.
what has research shown abt orilstat effectiveness for weigh loss and side effects?
orlistat reduced weight by 2-9%.
Attrition (quitting study) rates were high ~33%.
Fatty and oily stool, faecal urgency, oily spotting, faecal incontinence in 7%
other disadvantages of orlistat
Possible deficiencies of fat-soluble vitamins
No long-term data on orlistat on obesity-related morbidity and mortality
what type of drug (based on action mech) is liraglutide/ saxenda
Long-acting glucagon-like peptide-1 receptor agonist from Novo Nordisk.
how do you take liraglutide
Daily injection.
what dose for t2d of liraglutide?
double
liraglutide ffectiveness weigh loss
4-5%
3 main cases where you would offer bariatric surgery
BMI of 40 kg/m2 or more
BMI of 35-40 kg/m2 and other co-morbidities
BMI of 30-34.9 kg/m2 for newly diagnosed T2DM.
what other criteria need to be considered if someone has the MBI and disease related criteria for surgery?
Past care:
– non-surgical measures have failed to achieve or maintain adequate clinically beneficial weight loss for at least 6 months
for during procedure:
– generally fit for anaesthesia and surgery
future care:
– commit to the need for long-term follow-up.
– receiving or will receive intensive specialist management
what specific group is surgery a first line option?
BMI >50 kg/m2
