Oncogenes Flashcards by abigail greene | Brainscape

Q

BCL-2

A

Antiapoptotic

GOF –> lymphoma

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Q

BRAF

A

Encodes serine/threonine kinase

GOF –> melanoma, NHL

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Q

c-kit

A

Encodes cytokine receptor

GOF –> GI stromal tumor

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Q

c-myc

A

TF

GOF –>Burkitt lymphoma

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Q

HER2/neu (c-erbB2)

A

Encodes tyrosine kinase

GOF –> breast, ovarian, gastric carcinoma

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Q

L-myc

A

TF, lung tumor

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Q

N-myc

A

TF

GOF –> neuroblastoma

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Q

RAS

A

Encodes GTPase

GOF –> colon, lung, pancreatic cancer

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Q

RET

A

Encodes tyrosine kinase

MEN2A and B, medullary thyroid cancer

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Q

BCR-ABL

A

Encodes tyrosine kinase

GOF –> CML, ALL

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