Oncology

Question 0

Clofarabine

Answer 0

http://www.ncbi.nlm.nih.gov/pubmed/19576186

Question 1

MLL

Answer 1

Mixed lineage leukemia

Question 2

Vorinostat

Answer 2

ALL drug

HDAC inhibitor

Question 3

Mitoxantrone

Answer 3

ALL treatment

Question 4

Panobinostat

Answer 4

HDAC inhibitor

Used for ALL

Question 5

What HDAC inhibitor is synergistic with bortezomib

Answer 5

Vorinostat

Question 6

What is semaphorin4

Answer 6

Carried on surface of immune cells and interacts with neuropilin-1

Question 7

What is neuropilin?

Answer 7

nrp1- on regulatory T cells and interacts with Semaphorin

Question 8

MTORC1

Answer 8

The mTOR pathway consists of two protein complexes, in which mTOR, raptor and mLST8 proteins constitute to form the mTOR Complex 1 (mTORC1)

Question 9

mTORC2

Answer 9

mTOR, rictor and Sin1 proteins forming mTOR complex 2 (mTORC2). In cellular growth and associated prolife

Question 10

3 phases of oncogenesis

Answer 10

Breakthrough, expansion, invasive

Question 11

What constitutes majority of tumor stromal cells?

Answer 11

Cancer associated fibroblasts

Question 12

MDSCs

Answer 12

Myeloid derived suppressor cells

Question 13

Immunosuppressive cells include

Answer 13

MDSCs, M2 macrophages, type 2 NKT cells, Treg cells

Question 14

Role of PDE-5 inhibitors in tumors

Answer 14

Increase infiltration of activated CTLs into tumors and also tumor induced T cell proliferation

Dos regulate expression of Arg1, iNOS, Il-4 alpha in MDSCs

Question 15

MYD88

Answer 15

Myeloid differentiation primary response 88, links TLRs to NFkB activation

Question 16

Approved based on DRR in melanoma lesions in the skin and lymph nodes

Answer 16

Talimogene laherparepvec