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Pharm > Oral diabetic drugs > Flashcards

Oral diabetic drugs Flashcards

1
Q

MOA Glyburide

A

Close potassium channel -> depolarization insulin release

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2
Q

MOA Acarbose

A

block alpha glucosidase (brush border) can’t absorb glucose

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3
Q

S.e. Acarbose

A

flatulence; Gi upset carbs stay in gut

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4
Q

MOA Rosiglitazone

A

Binds PPAR-gamma nuclear transcription regular increase glucose uptake in cells

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5
Q

MOA Metformin

A

unknown; increases insulin sensitivity

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6
Q

MOA

Glitazones / thiazolidinediones

A

binds PPAR gamma nuclear transcription regulator;

this increases insulin sensitivity and weight gain

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7
Q

Meglitinides (repaglinide)

MOA

A

bind membrane ion channel

closes K+ channel on beta cell

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Pharm (6 decks)

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