parkinsons Flashcards
what are the motor signs present in someone with parkinsons disease
rigidity and head trembling, bradykinesia, shuffling gait short steps, reduced arm swinging, forward tilt of trunk, rigidity and trembling of extremities
describe the bilateral/unilateral nature of parkinsons
parkinsons disease one side is always more affected than the other, but both sides normally affected. one WORSE than the other
how do smoking and drinking affect Parkinson disease
smoking and drinking are protective
what is the mean age of onset for Parkinson disease a neurodegenerative disease
65 years
what happens in the brain when you have Parkinson
substantia niagra disappears in those with parkinsons, contains dopamine, this leaves parkinsons suffers wioth less dopamine, they also have lewy body inclusions in neurones of parkinsons which contributes to neurone damage
alongside dopamine system what other system contribute to parkinsons
The CNS is also affected which cause non motor symptoms aswell as motor systems
name some non motor symptoms of parkinsons
cognitive deficits, depression, diplopia, postural hypotension , constipation, reduced sense of smell,
what is hyposmia
reduced sense of smell can happen in parkinsons due to olfactory bulb being affected
RBD is a non motor symptom associated with parkinsons
acting out REM and may be injury partners and patients
what protein causes neurodegnerative damage in parkinsons
α-synuclein,