parkinsons Flashcards

1
Q

what are the motor signs present in someone with parkinsons disease

A

rigidity and head trembling, bradykinesia, shuffling gait short steps, reduced arm swinging, forward tilt of trunk, rigidity and trembling of extremities

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2
Q

describe the bilateral/unilateral nature of parkinsons

A

parkinsons disease one side is always more affected than the other, but both sides normally affected. one WORSE than the other

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3
Q

how do smoking and drinking affect Parkinson disease

A

smoking and drinking are protective

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4
Q

what is the mean age of onset for Parkinson disease a neurodegenerative disease

A

65 years

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5
Q

what happens in the brain when you have Parkinson

A

substantia niagra disappears in those with parkinsons, contains dopamine, this leaves parkinsons suffers wioth less dopamine, they also have lewy body inclusions in neurones of parkinsons which contributes to neurone damage

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6
Q

alongside dopamine system what other system contribute to parkinsons

A

The CNS is also affected which cause non motor symptoms aswell as motor systems

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7
Q

name some non motor symptoms of parkinsons

A

cognitive deficits, depression, diplopia, postural hypotension , constipation, reduced sense of smell,

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8
Q

what is hyposmia

A

reduced sense of smell can happen in parkinsons due to olfactory bulb being affected

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9
Q

RBD is a non motor symptom associated with parkinsons

A

acting out REM and may be injury partners and patients

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10
Q

what protein causes neurodegnerative damage in parkinsons

A

α-synuclein,

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