PATCH CLAMP, GABA RECEPTORS, GLUTAMATE RECEPTORS

Question 1

What are GABA receptors?

Answer 1

Receptors that bind to GABA - the main inhibitory neurotransmitter in the CNS

Question 2

What are the two types of GABA receptors?

Answer 2

GABA A - ligand gated ion channels
GABA B - G protein coupled receptors

Question 3

Describe the GABA A receptor

Answer 3

• They are coupled with benzodiazepine receptors
• They are ligand gated Cl- channels
• Diazepam and lorazepam are agonists for these receptors and they increase the affinity of the GABA binding site which increases the channel opening

Question 4

What is an inverse agonist of benzodiazepine?

Answer 4

• Beta Carbolines

Question 5

What is an antagonist of benzodiazapine?

Answer 5

Flumazenil

Question 6

Describe glutamate gated chloride receptors

Answer 6

• 5 subunits
• Important target for anti-parasitic drugs