Path WBC/RBC

Question 1

Which of the following is INCORRECT about erythropoietin?

Polycythemia vera increases erythropoietin
Renal carcinoma can produce erythropoietin
fatty liver disease also does this
Hypoxia + high altitude stimulates erythropoietin production

Answer 1

Polycythemia vera increases erythropoietin

Question 2

which of the following statements about reticulocytes is FALSE?

normal is 10%
Bone marrow response to anemia
Counts should be corrected for the anemia
High retic count is 10%
Inadequate retic response implies that the marrow is aplastic or dysplastic

Answer 2

normal is 10%

Question 3

Which of the following is NOT part of a complete blood count?

Answer 3

leukocyte alkaline phosphatase (LAP)

Question 4

Which of the following statements on hemoglobin F is INCORRECT?

• Shifts oxygen curve to the right
• oxygen more readily and thus less oxygen is unloaded
• Should be replaced by hemoglobin a by 97%
• Unconjugated bilirubin from the breakdown of fetal red cells
• Hemoglobin F gets broken down by splenic histiocytes thus physiologic jaundice

Answer 4

Shifts oxygen curve to the right

Question 5

which of the following is NOT a red cell inclusion?

o	Calgary A bodies
o	Holly jolly bodies
o	Basophilic stippling
o	Heinz bodies
o	Pathoheimic bodies

Answer 5

Calgary A bodies

Question 6

Which of the following are associated with microcytic anemias?

MCV <80
Iron deficiency anemia
Chronic disease
Sideroblastic anemia
all of the above

Answer 6

all of the above

Question 7

False about Kolinicha?

o almost never seen in iron deficient anemia
o finger nails become thin, brittle, and concave
o Spoon shaped
o Distal half

Answer 7

almost never seen in iron deficient anemia

Question 8

: Which of the following are features of iron deficiency?
o all of the above
o Serum iron is decreased
o total iron binding capacity is elevated
o saturation

Answer 8

A: all of the above

Question 9

Which of the following are CORRECT about anemia of chronic disease?
o all of the above
o Common
o Last longer than 1-2 months
o 25% of cases only chronic diseases present in the pt such as CHF
o usually anemia is mild to moderate with a hematocrit >25%
o serum iron is reduced
o iron binding capacity is reduced
o percent saturation may be

Answer 9

all of the above

Question 10

Which of the following statements regarding bthal is CORRECT?
o all of the above
o B thal includes severe, moderate, and mild, major, intermediate, minor
o B thal major is a homozygous disease
o B thal is caused by inheritance of two b thal alleles resulting in little to no b chain
o A chain synthesis remains normal in b thal

Answer 10

all of the above

Question 11

which of the following statements regarding macrocytic anemia is INCORRECT?

Answer 11

cause of macrocytic anemia in alcoholics is a deficiency of B12 and folate

Question 12

the following are expected lab results in hemolytic anemia EXCEPT?
o	haptoglobin increases
o	Polychromatic philia
o	Indirect bil increases
o	Serum LDH increases
o	Retic > 3

Answer 12

haptoglobin increases

Question 13

Spherocytes can be seen in?

Answer 13

everywhere

Question 14

Teardrop cells seen in?
o	all of the above
o	myelofibrosis
o	Hemolysis
o	Megaloblastic anemia
o	Cancers of BM: BM infiltration, mylocystic syndrome, metastases

Answer 14

all of the above

Question 15

Which of the following statements about parvovirus B19 is CORRECT?
o all of the above
o Can cause red cell aplasia
o Bone marrow aspirate smears usually show giant erythroblasts
o The erythroblasts on BM show intranuclear viral inclusion
o The erythroid inclusion show blasty intranuclear inclusions called Lantern cells

Answer 15

all of the above

Question 16

Which of the following is NOT a myledysplastic syndrome?
o Chronic neutrophilic leukemia
o Refractory anemia
o Refractory anemia of ring sideroblast
o Refractory cytopenia with multilineage dysplasia (RCMD)

Answer 16

Chronic neutrophilic leukemia

Question 17

: Which of the following statement regarding systemic mastocytosis are CORRECT?
o all of the above
o You should see dense infiltrates of mast cells in the bone marrow
o You can see extra cutaneous organ involvement >15% mast cells
o Mast cells stain with
o A minor criteria of mast cells seen in bone marrow >25%

Answer 17

all of the above

Question 18

which of the following statement regarding primary myelofibrosis is NOT correct?
o 75% of cases transformed into AML
o Mean age is 60 yrs
o Rarely occurs in kids
o Mylofibrosis is a clonal stem cell defect with pan myelopathy
o Can see extramedullary hematopoiesis in lymph node
o Fibrosis is due to neoplastic megs releasing growth factor

Answer 18

75% of cases transformed into AML

Question 19

• Which of the following statements regarding essential thrombocytopenia is false?

Answer 19

o JAK2 mutation is rare

Question 20

which of the following of polycythemia veria is INCORRECT?
o without treatment patients live 5-10 years
o Jack2 mutation in 97%
o Must differentiation pvera for reactive process
o Pvera erythropoietin levels are decreased and o2 stats are normal
o Can be due to lung disease

Answer 20

without treatment patients live 5-10 years

Question 21

All of the following of myeloproliferative disorders EXCEPT?
o	multiple mylenoma
o	Chronic myelogenous leukemia
o	Polycypenia vera
o	Essential thrombocythemia
o	Primary myelofibrosis

Answer 21

multiple mylenoma

Question 22

: Which of the following statements regarding mycosis fungoides is correct
o all of the above
o Single most important prognostic factor is clinical stage
o Limited diseases has excellent prognosis, survival similar to normal population
o Adverse prognostic parameters include: disseminated disease, >60 yrs, high LDH
o 25% of peripheral involvement of blood is called Szery syndrome

Answer 22

all of the above

Question 23

Which of the following statements about mycosis fungoides is INCORRECT?
o cutaneous T cell lymphoma is an extremely rare primary cutaneous lymphoma
o CTL often misdiagnoses as psoriasis
o Multiple skin lesions that progress from sclaes to plaques

Answer 23

cutaneous T cell lymphoma is an extremely rare primary cutaneous lymphoma

Question 24

\: The diagnostic criteria for chronic lymphocytic leukemia (CLL), which of the following is true?
o	all of the above
o	Absolute lymphocytosis > 5%
o	>30% lymphocytosis in BM
o	monoclonal B cells with CD5 + CD20
o	peripheral blood smear of smudge cells

Answer 24

all of the above

Question 25

Which of the following statements about T cell acute lymphoblastic leukemia (TALL) is correct?
o	all of the above
o	Expresses CD2 + CD28
o	Blasts are CD10-
o	Seen in teenagers
o	Often seen with mediastinal mass

Answer 25

all of the above

Question 26

which of the following statements about b cell acute lymphoblastic leukemia (B cell ALL)
o all of the above
o Good prognosis with translocation 12,21
o Translocation 12, 21 often seen in kids
o Poor prognosis with 9,22
• Philadelphia chromosome
o More common in adults

Answer 26

all of the above

Question 27

Which is false about ALL

Answer 27

B all has a poor response to chemo

Question 28

which of the following statement about ALL are correct?
o all of the above
o Malignant proliferation of lymphocytes
o Most in kids
o When associated with DS, can happen under the age of 5
o Lymphoblasts stain with TDT
o Absent in myeloblasts

Answer 28

all of the above

Question 29

which of the following are unfavorable genetic abnormalities in AML

Answer 29

deletion of 5q-

Question 30

• Q: Which of the following WHO classifications for myelogenous leukemia are INCORRECT?
o all of the above
o Acute myeloid leukemia with recurrent genetic abnormalities
o Acute myeloid leukemia with multiple lineage dysplasia
o AML with myelodysplastic syndrome
o Therapy related AML
o AML not otherwise classified

Answer 30

all of the above

Question 31

Which of the following are NOT unfavorable prognostics for AML?
o	young kids who respond to chemotherapy
o	Patients under the age of 2
o	Marked leukocytosis
o	History of myelodisplasia
o	FLT3

Answer 31

young kids who respond to chemotherapy

Question 32

Which of the following are true about AML
o all of the above
o Malignant proliferation of immature cells
o CD34+
o Antimyloperoxidase stains in myeloblasts
o Aggregates of MPO are Auer Rods

Answer 32

all of the above

Question 33

causes of monocytosis

Answer 33

• Chronic inflammation
• Autoimmune
• Infection
• Malignancy

Question 34

causes of leukocytosis

Answer 34

• Bacterial infections
• Tissue necrosis
• Release of marginated cells from BM
• High cortisol states

Question 35

Haptoglobin

Answer 35

does NOT increase in hemolytic anemia