Pathology

Question 1

AD peripheral nerve disorder associated with scoliosis and foot deformities

Answer 1

Charcot-Marie-Tooth disease (hereditary motor and sensory neuropathy)

Question 3

Name the CNS neoplasm:

Pediatric patient

Rosettes

Small basophilic cells

Answer 3

Medulloblastoma

Question 4

increased CSF protein with normal cell count

Answer 4

GBS

(this is called albuminocytologic dissociation)

Question 4

Glioblastoma multiforme stain positive for ___

Answer 4

GFAP

Question 5

Name the dementia:

visual hallucination

alpha-synuclein

Answer 5

LBD

Question 5

Peripheral neuropathy

Developmental delay

optic atrophy

globoid cells

galactocerebrosidase deficiency

Answer 5

Krabbe disease

Question 5

Pseudopalisading tumor cells describes what brain malignancy

Answer 5

glioblastoma multiforme

Question 6

tonic vs clonic

Answer 6

tonic: stiffening
clonic: movement

Question 7

Skin tumors in NF1 derived from what cell line

Answer 7

neural crest

Question 8

Central or peripheral vertigo

Delayed horizontal nystagmus:

Immediate nystagmus in any direction:

Answer 8

Delayed horizontal nystagmus: peripheral

Immediate nystagmus in any direction: central

Question 9

Name the CNS neoplasm:

Closely arranged, thin-walled capillaries with minimal intervening parenchyma

EPO pruducing

Answer 9

Hemangioblastoma

Question 9

Name the CNS neoplasm:

Round nuclei with clear cytoplasm

Located in frontal lobe

Answer 9

oligodendroglioma

Question 11

Name renal and cardiac manifestations of tuberous sclerosis

Answer 11

Renal angiomyolipoma

Cardiac rhabdomyoma –> mitral regurg

Question 12

Name the CNS neoplasm:

4th ventricle

perivascular rosettes

Rod-shaped blepharoplasts near nucleus

Answer 12

ependymoma

Question 13

Name the CNS neoplasm:

Pediatric patient

Rosenthal fibers – eosinophilic corkscrews

Answer 13

Pilocytic astrocytoma

Question 15

Most common partial seizure location

Answer 15

medial temporal lobe

Question 16

Cluster HA gender predominance

Answer 16

male

Question 17

Familial retinoblastoma increases risk for this non-ophthalmologic malignancy

Answer 17

osteosarcoma

Question 19

arylsulfatase A deficiency

ataxia

dementia

Answer 19

metachromatic leukodystrophy

Question 20

Uncal herniation

Left homonymous hemianopia

Did the left or right uncus herniate?

Answer 20

Right

Question 21

Name the brain malignancy:

spindle cells concentrically arranged in a whorled pattern

Psammoma bodies

Answer 21

meningioma

Question 22

Port-wine stain in CN V1/V2 distribution

epilepsy

leptomeningeal angioma

glaucoma

retardation

GNAQ mutation

Answer 22

Sturge Weber

(note that this is sporadic, not inherited)

Question 23

Hemangioblastomas in retina, brain stem, cerebellum, spine

angiomatosis

bilateral RCC

Pheos

Answer 23

von Hippel-Lindau