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Endocrine > Pathology > Flashcards

Pathology Flashcards

1
Q

C cells secrete

A

calcitonin

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2
Q

Antibodies in Grave’s disease

A

TRAb, anti-TPO, thyroglobulin Ab

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3
Q

Antibodies in Hashimoto’s

A

thyroglobulin Ab, anti-TPO

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4
Q

Nodules in MNG

A

Thyroid adenoma

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5
Q

Mets in papillary carcinoma

A

Lymphatic

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6
Q

Mets in follicular carcinoma

A

Haemagtogenous

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7
Q

Medullary thyroid carcinoma is derived from:

A

C cells

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8
Q

Medullary carcinoma associated with:

A

MEN2

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9
Q

2 types of cells in PT gland

A

Chief cells and Oxyphil cells

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10
Q

Chief cells secrete

A

PTH

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11
Q

Oxyphil cells

A

Support

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12
Q

Hypoparathyroidism associated with:

A

DiGeorge or post-op

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13
Q

Other names for anterior and posterior pituitary

A

Adenohypophysis and Neurohypophysis

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14
Q

Cells in anterior pituitary

A

Acidophils and Basophils

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15
Q

Acidophils

A

Somatotrophs (GH), Mammotrophs (PRL). pink

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16
Q

Basophils

A

Corticotrophs (ACTH), Thyrotrophs (TSH), Gonadotrophs (FSH/LH). purple

17
Q

Initial stages of steroid production

A

Cholesterol to pregnenolone

18
Q

Adrenocortical carcinoma spread

A

haematogenous

19
Q

Conn’s syndrome

A

Primary hyperaldosteronism (adenoma or hyperplasia)

20
Q

Secondary hyperaldosteronism

A

Increased renin due to hypovolaemia/pregnancy

21
Q

Cushing’s

A

Hypercortisolism - steroids, pituitary adenoma, ectopic ACTH (small cell lungs)

22
Q

Primary adrenocortical insufficiency

A

Fast withdrawal of steroids, infection in chronic hypocortisolism, Addison’s

23
Q

Addison’s disease

A

Primary adrenocortical insufficiency, silent until 90% destroyed

24
Q

2 tumours of adrenal medulla

A

Phaeochromocytoma, Neuroblastoma

25
Q

Neuroblastoma

A

In adrenal medulla or sympathetic chain

26
Q

Phaemochromocytoma

A

A paraganglioma arising from chromaffin cells, secretes catecholamines

27
Q

MEN2 involves

A

Phaeochromocytoma, medullary thyroid carcinoma, PT hyperplasia (Sipple syndrome)

Endocrine (13 decks)

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