Pathophysiology lecture 1 Flashcards

1
Q

Pathophysiology is what went ________or Why is somebody who is healthy getting _____

A

wrong; sick

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2
Q

______________ is can we change it

A

pharmacology

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3
Q

___________ is how do we change it…what do we need to do and how does this work

A

Therapeutics

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4
Q

What is Health?

A

Not sick, how body feels over time, no illness

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5
Q

_________ is the study of body function

A

Physiology

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6
Q

____________is the study of
the body’s response to
dysfunction or disease

A

Pathophysiology

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7
Q

_________ is a state of complete physical, mental, and social wellbeing and not merely the absence of disease and infirmity

A

Health

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8
Q

_____________
The interruption, cessation, or
disorder of a body system or
organ structure.

A

Disease

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9
Q

Aspects of the Disease Process
*Etiology
*Pathogenesis
* Morphologic changes
*Clinical __________
*Diagnosis
*Clinical course

A

manifestations

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10
Q

Pathophysiology is the study of the body’s response to dysfunction or disease. It’s not just the disease process but its how the body responds to that issue. Ex:tuberculosis

A
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11
Q

Tuberculosis itself isn’t doing that much to the body but the body has a really hard time getting rid of it and it goes into overdrive and most of the damage you see that occurs because of the tuberculosis is because the body is responding so forcefully and its hitting it with so many antibodies and cytokines and such a strong immune response that it damages the system

A
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12
Q

We need to not only consider what the disease is but how the body is responding to it and how the body is changing to it (Sometimes you will hear about symptomatic treatment where your treating the side effects maybe the symptoms that may not actually be the root cause of the disease and we want to know what the root cause is and deal with it. Sometimes we have to deal with what the body is doing because its sick so we will lower the fever but that doesn’t change anything makes you feel better maybe but you have a fever for a reason and we got to treat both. It’s not only the disease but it’s the bodies response that we have to look at

A
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13
Q

Etiologic Factors
*Causes of Disease –
__________(e.g., bacteria, viruses),
Physical forces (e.g., trauma,burns, radiation)
__________ (e.g., poisons, alcohol)
Nutritional excesses or deficits (ex:anemia)
-Prescriptions or over the counter drugs can cause a problem

A

Biologic agents, chemical agents

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14
Q

Factors Affecting Adaptation to Stressors
* _______
* _______ status
* Psychosocial resources
* The ______with which the need to
adapt occurs
* The availability of adaptive responses
and the ability of the body to select
the most appropriate response

A

Age, Health,speed

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15
Q

Factors affecting adaptation to stressors:
_______-Young people have a better immune system and respond to stress better as opposed to an infant or an elderly person.

Health status-Are you generally healthy or does your body have any comorbidities that you have to deal with and overcome

__________ resources-Do you have friends/family you can lean on; are you by yourself; is there anyone you can turn to for help it can make all the difference in a stressful situation

The speed with which the need to adapt occurs (is it an emergency or is it slow; sometimes we can deal with things better if we have a little time to prepare or understand

The availability of adaptive responses and the ability of the body to select the most appropriate response

A

Age,psychosocial

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16
Q

Factors Derived Using Epidemiologic Methods:
How the disease is ________
How to ________ disease
How to prevent disease
How to eliminate disease

A

spread, control

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17
Q

How does a disease spread?

Through ___________ or direct contact, airborne disease, vectors, _________ like blood, or sexual contact, blood transmitted or sexually transmitted diseases

A

physical, bodily fluids

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18
Q

How to control and prevent disease?

Reduce contact by ________, glove, hygiene, personal protective equipment, distancing, __________, vaccinations, medications, education

A

mask,quarantines

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19
Q

How to eliminate disease?

-___________
-isolation
-quarantine

A

Medication

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20
Q

_________=designation of the nature or cause of a health problem

A

Diagnosis

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21
Q

_____=the extent to which an observation, when repeated, gives the same results (If I do the test do I get the same results, Doesn’t say if it’s the right result though)

A

Reliability

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22
Q

____= will tell you whether its actually correct or not, how valid is that result; the extent to which a measurement tool measures what it is intended to measure

A

Validity

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23
Q

We need both _________and ________in order to determine whether something is working properly

A

reliability and validity

24
Q

______________: use the simultaneous collection of information necessary for classification of exposure and outcome status

A

Cross-sectional studies

25
Q

_________: compare case
subjects to control subjects

Hint in the definition :)

A

Case-Control studies

26
Q

____________: involve groups of
people born at the time or who share
some factor. (Framingham study; study people who were born in Framingham or around the same time for pretty much their whole lives; take people that share a factor they were born at the same time and the same place)

A

Cohort studies

27
Q

__________: number of new cases in a population(ex: new cases of COVID)

A

Incidence

28
Q

_____________ is how often it happens or how common it is within a population; TOTAL (ex: How many people total have COVID?)

A

Prevalence

29
Q

For something like infectious disease that comes and goes prevalence is not as important; this matters in cancer

A
30
Q

Total prevalence of breast cancer;
whats the total prevalence of breast cancer how many people have it at a given time over ten years but how many new cases are there is there an increase in new cases over the past 6 months is there a decrease

A
31
Q

________ is new cases; recently appeared in some given time frame; number of new cases in a given time frame

A

Incidence

32
Q

________ is total what percent of the total population has it (ex: the number of people that have natural immunity now; had covid over the two year span);total number of cases in a given time frame

A

Prevalence

33
Q

_________is how many people have it currently and are active?

A

Incidence

34
Q

____________: true positive rate (ex: want to see how many people have the flu and 6 do have it my sensitive test would detect that all 6 of you have the flu; how many positive cases do you actually detect; how low it can detect something

A

Sensitivity

35
Q

________: how many negative cases are truly negative; false positive; if a test is 100% sensitive and says everybody has it and they don’t that’s NOT useful; (ex:prostate specific antigen; males have had a PSA test; used to be a biomarker used to detect if somebody may be at risk for prostate cancer.. its a bad marker and the specificity of it might be high and people actually didn’t have it so it wasn’t a good test it was giving a lot of false positives saying people had cancer but didn’t

A

Specificity

36
Q

________=ability of a test to correctly identify those with the disease (true positive rate)

A

Sensitivity

37
Q

_________=ability of the test to correctly identify those without the disease (true negative state)

A

Specificity

38
Q

Both sensitivity and specificity numbers need to be high in order for this to work effectively

A
39
Q

__________: anything negative (ex:injury,illness); state of diseased or unhealthy in the population
-Condition of disease

A

Morbidity

40
Q

________: death rate; number of dead in the population

A

Mortality

41
Q

____________: trying to stop something before it starts (ex:immunization); NO disease..trying to prevent disease; removing risk factors so disease DOES NOT occur

A

Primary Prevention

42
Q

____________: (ex:screening, pap smear ) trying to prevent something from getting worse; nothing you can see physically or don’t feel like anything is wrong but something is detectable by a lab like a colonoscopy or mammogram; laboratory needed to detect disease no interference with life other wise; asymptomatic disease

A

Secondary prevention

43
Q

_________: prevent disease from getting worse you know you have it you have symptoms its interfering in some way your trying to do things to prevent it from getting worse this is a diabetic starting an exercise plan trying to prevent there diabetes from getting worse; measurable differences there is a disease present your just trying to prevent it from getting worse; already interfering with life just trying to prevent it from getting worse; preventing further deterioration, reducing complications of disease

A

Tertiary prevention

44
Q

Which of the following prefixes is used to indicate a lack of something? The prefix

A

-a

45
Q

Which of the following prefixes is used to indicate that something is difficult or painful?

A

Dys

46
Q

Which of the following suffixes is used to indicate flow?

A

-rrhea

47
Q

(Prefix of -poiesis means generation; is making)

A
48
Q

Which of the following prefixes is used to indicate something “moving away” from?

A

-ab

49
Q

____is bringing in

(ex:admission)

A

Ad

50
Q

Which of the following prefixes is used to indicate something is extreme or too much?

A

Hyper

51
Q

Which of the following suffixes is used to indicate something that is inflamed?

A

itis

52
Q

Which of the following suffixes is used to indicate something that is deficient in number?

A

Penia

53
Q

Tachy is _______, increase (ex: tachycardia=fast heartbreat)

A

fast

54
Q

Ectomy is usually cutting something out

A
55
Q

Which of the following suffixes is used to indicate something painful?

A

Algia

56
Q

SensiTivity = True that are True (Patients found to have disease that do have the disease)

A
57
Q

SpeciFicity = False that are False (Patients found to not have the disease who do not have the disease)

A