PCOS

Question 1

Diagnostic criteria for PCOS?

Answer 1

Hyperandrogenism, ovulatory dysfunction, polycystic ovaries (in one or both ovaries, either 12+ follicles measuring 2-9mm or increased ovarian volume (greater than 10cm3)

Question 2

Facts on androgens?

Answer 2

75% testosterone made in ovary. Secretes androstenedione and dihydrotestosterone=most potent androgen, results primarily from intracellular 5-alpha reduction of testosterone.

Question 3

What are 3 treatments for hirsutism?

Answer 3

Spironolactone, Flutamide, Finasteride

Question 4

What is spironolactone?

Answer 4

Spironolactone: androgen-R antagonist. Aldosterone antagonist and diuretic. Can cause menstrual irregularity.
- SE: vomiting, dizziness, bleeding, mastalgia

Question 5

What is finasteride?

Answer 5

Finasteride: inhibits 5-alpha reductase (which converts testosterone into DHT-most potent androgen). Teratogenic in male fetuses.

Question 6

What is Flutamide?

Answer 6

Flutamide=androgen-R agonist. Common side effect=dry skin, rarely hepatitis.