Penicillins

Question 1

Beta lactams are ____ to the cell wall

Answer 1

Bactericidal

Question 2

Beta lactams show ___ dependent killing

Answer 2

Time

Question 3

Beta lactams work by interfering with _____ which are called ____ and used for ____

Answer 3

Penicillin binding protein
Transpeptidase
Catalyst cross linking process

Question 4

Penicillins have a ____ therapeutic index

Answer 4

High

Question 5

Penicillins are
A. Unstable
B. Stable
In solutions

Answer 5

A

Question 6

Beta lactams are best given as ____

Answer 6

IV infusion
Bolus
In normal saline

BNF SAYS 5% glucose or 0.9% NaCl

Question 7

Most sensitive bacteria to penicillin G (benzoyl) are

Answer 7

Strep pyogenes

Meningococcus

Question 8

Benzyl penicillin can be used for pneumonia

t/F

Answer 8

True

Question 9

What are aminopenicillins used against and not against

Answer 9

NOT FOR KLEB AND PSEUDO

for proteus
Salmonella
Shigella
All gram +ve that was susceptible to benzyl

Question 10

Benzathine penicillin is given

IM
IV
ORAL

Answer 10

ONLY IM

Question 11

_______ competes with penicillins for elimination

Answer 11

Probenecid

Question 12

Amoxycillin has a _____ bioavailability than Ampicillin

Answer 12

Better

Question 13

Penicillins are
Safe
Not safe
In pregnancy

Answer 13

Safe

Question 14

Penicillins can cross BBB

Answer 14

Only when meninges inflamed

Question 15

Treatment for strep throat

Answer 15

Simple- phenoxy or procaine for 10 days

Or single dose benzathine IM

Question 16

Treatment of severe strep throat with spread

Answer 16

Benzyl or procaine

Question 17

Combination of penicillin and aminoglycosides is an example of _____

Answer 17

Synergism

Question 18

Treatment for endocarditis is for _____

Answer 18

4-6 weeks

Question 19

Name 5 hypersensitivity reactions apart from bronchospasm urticaria fever MP rash

Answer 19

Contact dermatitis (4)
Serums sickness (3)
Hemolytic anemia (2)
Vasculitis SJ syndrome exfoliating dermatitis (1)

Question 20

Explain intradermal skin test

Answer 20

Dilute benzyl p
1:100000 U/ml

Inject 0.02 ml

Look for rash >3mm

Question 21

Side effect of coamoxiclav

Answer 21

Liver toxicity

Shows jaundice

Question 22

Which is more effective against gram streptococcus

Amino penicillin
Benzyl

Answer 22

Benzyl

Question 23

Aminopeni drug interaction

Answer 23

Failure of contraceptives

Question 24

Group 4 pen drug reaction

Answer 24

Dose related anti platelet effect

Cautious with aspirin

Question 25

Mode of administration for anti pseudomonas

Answer 25

IV ONLY

bc acid labile

Question 26

Penicillin used for osteomyelitis

Answer 26

Fluclox

Question 27

Antibiotic for salmonella shigella proteus h influenza

Answer 27

Aminopen

Question 28

Antibiotic for spirochettes

Answer 28

Penicillin G (benzyl)

Question 29

Antibiotic for Lyme disease

Answer 29

Amino