Peripheral Nervous System PNS Overview Flashcards
Peripheral nervous system( PNS) overview
It's the autonomic nervous system
Maintain balance ( homeostasis)
Function is involuntary.
Smooth muscle
Cardiovascular
Bronchi
GI tract
Bladder
IrisSympathetic nervous system
Adrenergic, sympathiminmetic ( fight or flight)
CV: ⬆️HR, vasoconstriction⬆️BP
Pulmonary: brinchodialation
GI:⬇️peristalsis/motility,⬇️saliva production
Liver:⬆️glycogenolysis and gluconeogesis➡️⬇️glucose
Renal: ⬇️urine output(UOP), urinary retention
Eyes: pupil dilation
Adrenergic agonist agents (SNS)
Adrenergic antagonist agents(SNS)
S/E: tachycardia, papiltations, hypertension, anxiety, tremor
S/E: orthostatic hypotension bradycardia
Adrenergic agonist drug
Epinephrine
Noncelective alpha and beta Indication Cardiac arrest, bronchoconstriction, anaphylaxis.
Adrenergic agonist drug
Albuteral
Levabuterol
Selective beta2 adrenergic agonist
Indications:
Short acting bronchodialator, used for rescue
Adrenergic agonist drug
Salmeterol
Selective beta2 adrenergic agonist
Indications long acting bronchodialator, used as a controller
Adrenergic agonist
Pseudoephedrine
Blood vessel constrictor
Indications nasal decongestant
Adrenergic antagonist agents
Doxazosin
Prazosin
Alpha1 blocker
Indication:
HTN and urinary obstruction with BPH
Adrenergic antagonist agents
Metoprolol
Atenolol
Cardioselective beta adrenergic blocker
Indications:
⬇️HR and BP, migraine headaches
Adrenergic antagonist agents
Phentolamine
Alpha1 blocker
Indication:
Infiltration of vasoconstrictor drug, which is infusing intravenously, in order to dialate vessels rapidly
Parasympathetic nervous system( PSNS)
Cholinergic, parasympathomimetic ( rest and digest)
Stimulation effects.
CV: ⬇️HR, changes BP
Pulmonary: bronchoconstriction
GI: ⬆️peristalsis/motility, ⬆️saliva production
Liver: changes in glycogen/fat breakdown
Renal: ⬆️UOP
Eyes: pupils constrict
PSNS
Cholinergic agonist agents
Donepezil
Action⬆️ concentrations of acetylcholine in the brain
Indication is treatment of mild to moderate Alzheimer’s disease
PSNS
Cholinergic agonist agents
Pyridostigmine
⬇️acetylcholinesterase➡️⬆️acetylcholine.
Indications treatment of myasthenia gravis; reverses non-depolarizing neuromuscular blocking agents
PSNS
Cholinergic agonist agents
Side effects
Salivation Lacrimation Urination Diarrhea GI cramping Emesis
PSNS
Cholinergic antagonist
Side effects
Mad as a hatter: confusion
Blind as a bat: blurred vision
Red as beet: facial flushing
Dry as a bone:decrease secretions
