Peripheral Neuropathies Flashcards

1
Q

What is carpal tunnel syndrome

A

Compression of the median nerve passing through the carpal tunnel in the wrist

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2
Q

What are the nerve roots of the median nerve

A

C6-T1

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3
Q

What are the two primary causes of compression in Carpal Tunnel Syndrome?

A
  • Swelling of the contents (e.g., tendon sheaths due to repetitive strain).
  • Narrowing of the carpal tunnel.
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4
Q

Which branch of the median nerve responsible for sensory innervation of the hand is affected in carpal tunnel syndrome

A

Palmar digital cutaneous branch

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5
Q

What are some key risk factors associated with Carpal Tunnel Syndrome? (5)

A
  • Age 40-60
  • Female
  • High BMI
  • Pregnancy
  • Diabetes, hypothyroid, acromegaly
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6
Q

How does Carpal Tunnel Syndrome typically present in terms of symptom onset and characteristics?

A
  • Onset: gradual, initially intermittent and often worse at night
  • Sensory: numbness, paraesthesia, pain
  • Motor: weak pincer grip & thumb movements - difficulty opening jars, thenar muscle wasting
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7
Q

Which part of the hand is typically spared in Carpal Tunnel Syndrome, and why?

A

The palm is usually spared because the palmar cutaneous branch, responsible for its innervation, does not travel through the carpal tunnel.

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8
Q

What are the two special tests used for Carpal Tunnel Syndrome?

A

Phalen’s test
Tinel’s test

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9
Q

What is considered the diagnostic test of choice for Carpal Tunnel Syndrome and what would be a positive finding?

A

Electromyography (EMG).
* focal slowing of conduction velocity in the median sensory nerves across the carpal tunnel

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10
Q

What are the management options for Carpal Tunnel Syndrome?

A

*Rest and altered activities.
* Wrist splints - neutral position, worn every night for 1-2m
* Steroid injections: methylprednisolone
* Severe= surgical release

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11
Q

In surgical intervention for Carpal Tunnel Syndrome, what structure is typically cut to release pressure on the median nerve?

A

The flexor retinaculum, aka the transverse carpal ligament

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12
Q

What is the most common mononeuropathy

A

Carpal tunnel syndrome

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13
Q

What are the nerve roots of the median nerve

A

C5-T1

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14
Q

What group of muscles does the radial nerve mainly innervate

A

Extensor muscles of the hand

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15
Q

How does a radial nerve palsy present

A

Wrist drop

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16
Q

What is the most common cause of foot drop

A

lesion of the L5 nerve root

17
Q

What is peripheral neuropathy

A

Reduced sensory and/or motor function in peripheral nerves

18
Q

Give 5 causes of peripheral neuropathy

A

Alcohol
B12 deficiency
Cancer and CKD
Diabetes and Drugs
Vasculitis

19
Q

State 3 drugs that can cause peripheral neuropathy

A
  • Amiodarone
  • Cisplatin
  • leflunomide
20
Q

What is the typical presentation of peripheral neuropathy

A
  • Numbness and tingling in hands/feet
  • Muscle weakness
  • Loss of balance
21
Q

Describe the characteristic distrubution of polyneuropathy pathology

A

Usually symmetrical and starts distally - glove and stocking distribution

22
Q

Give 3 pathological mechanisms resulting in peripheral neuropathy

A
  • Demyelination
  • Axonal degeneration
  • Nerve compression
23
Q

Give 4 conditions that cause polyneuropathy and state whether they are mostly motor or sensory symptoms

A
  • Guillain Barre - motor
  • Charcot Marie Tooth
  • Diabetic neuropathy - Sensory (mc)
  • Renal failure - sensory
24
Q

Give 3 sensory characteristics of polyneuropathy

A
  • Signs of trauma (e.g. burns)
  • Difficulty handling small objects
  • Pain
25
Q

Give 4 motor characteristics of polyneuropathy

A
  • progressive
  • Weak/ clumsy hands
  • Difficulty walking
  • LMN signs
26
Q

How are polyneuropathies managed

A
  • Treat the cause
  • Physio
  • Podiatrist
  • Analgesia for neuropathic pain (e.g. amitriptyline, pregabalin)